INT22771

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 44
Total Number 52
Disease Relevance 16.45
Pain Relevance 8.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
salivary gland 3
margin 2
gastric juice 2
neurons 2
Notch 1
Egf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 39 100.00 Very High Very High Very High
agonist 202 99.84 Very High Very High Very High
metalloproteinase 45 99.60 Very High Very High Very High
Nicotine 30 99.58 Very High Very High Very High
nociceptor 66 98.76 Very High Very High Very High
peptic ulcer disease 8 98.60 Very High Very High Very High
Kappa opioid receptor 6 98.56 Very High Very High Very High
cytokine 189 98.48 Very High Very High Very High
Nerve growth factor 398 98.46 Very High Very High Very High
B1 receptor 1 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Leukemia 5 100.00 Very High Very High Very High
Ulcers 119 99.98 Very High Very High Very High
Apoptosis 26 99.90 Very High Very High Very High
Hiatal Hernia 9 99.62 Very High Very High Very High
Salivary Gland Disease 13 99.56 Very High Very High Very High
Stress 317 99.38 Very High Very High Very High
Nicotine Addiction 32 99.32 Very High Very High Very High
Injury 92 99.22 Very High Very High Very High
Enteropathy 1 98.96 Very High Very High Very High
Reprotox - General 1 9 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect of estradiol does not appear to be due solely to an induction of tissue EGF receptors.
Positive_regulation (induction) of EGF
1) Confidence 0.70 Published 1987 Journal FASEB J. Section Abstract Doc Link 3497834 Disease Relevance 0.08 Pain Relevance 0.08
Ulcer induction by itself dramatically elevated EGF levels in salivary glands and serum on day 1 and 4, and also in the gastric mucosa on day 4.
Positive_regulation (induction) of EGF in salivary glands associated with salivary gland disease and ulcers
2) Confidence 0.70 Published 2000 Journal Life Sci. Section Abstract Doc Link 11210723 Disease Relevance 0.88 Pain Relevance 0.61
Theophylline at dose of 85mgkg(-1) increased EGF concentration to 60% (P<0.01) of control.
Positive_regulation (increased) of EGF
3) Confidence 0.69 Published 2003 Journal Pharmacol. Res. Section Abstract Doc Link 12967588 Disease Relevance 0 Pain Relevance 0.08
Sildenafil at doses of 2 and 5mgkg(-1) increased EGF concentration to 44% (P<0.05) and 90% (P<0.01) of control, respectively.
Positive_regulation (increased) of EGF
4) Confidence 0.69 Published 2003 Journal Pharmacol. Res. Section Abstract Doc Link 12967588 Disease Relevance 0 Pain Relevance 0.07
The Na+ effect was concentration-dependent (maximal effect, </=12.5 mM) and was specific for shear stress-mediated ERK1/2 activation as epidermal growth factor-stimulated ERK1/2 activation was unaffected by removal of extracellular Na+.
Positive_regulation (activation) of epidermal growth factor associated with stress
5) Confidence 0.67 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10400628 Disease Relevance 0.68 Pain Relevance 0.35
All patients undergoing esophagogastric fundoplication (EGF) with a Collis gastroplasty for the management of gastroesophageal reflux disease or paraesophageal hernia were identified from a prospectively maintained database.
Positive_regulation (undergoing) of EGF associated with hiatal hernia and gastroesophageal reflux disease
6) Confidence 0.49 Published 2004 Journal J. Gastrointest. Surg. Section Abstract Doc Link 14746833 Disease Relevance 0.24 Pain Relevance 0
In contrast, isoproterenol (ISO) (0.01-10 mg/kg i.g.), beta-adrenoceptor agonist, reduced dose-dependently ethanol-induced mucosal injury and this effect was accompanied by an elevation of the GBF similarly as after epidermal growth factor (EGF) (100 microg/kg x h s.c.) or after classic protective agent, 16,16-dimethyl-PGE2 (PGE2) (10 microg/kg i.g.).
Positive_regulation (elevation) of EGF associated with injury and agonist
7) Confidence 0.49 Published 1997 Journal Digestion Section Abstract Doc Link 9324159 Disease Relevance 0.10 Pain Relevance 0.41
The Na+ effect was concentration-dependent (maximal effect, </=12.5 mM) and was specific for shear stress-mediated ERK1/2 activation as epidermal growth factor-stimulated ERK1/2 activation was unaffected by removal of extracellular Na+.
Positive_regulation (activation) of epidermal growth factor associated with stress
8) Confidence 0.49 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10400628 Disease Relevance 0.68 Pain Relevance 0.35
The main aim of this investigation was to determine whether a functional relationship existed between epidermal growth factor (EGF) and voltage-gated sodium channel (VGSC) upregulation, both associated with strongly metastatic prostate cancer cells.
Spec (whether) Positive_regulation (upregulation) of epidermal growth factor associated with sodium channel and reprotox - general 1
9) Confidence 0.47 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 17960590 Disease Relevance 0.17 Pain Relevance 0.27
The main aim of this investigation was to determine whether a functional relationship existed between epidermal growth factor (EGF) and voltage-gated sodium channel (VGSC) upregulation, both associated with strongly metastatic prostate cancer cells.
Spec (whether) Positive_regulation (upregulation) of EGF associated with sodium channel and reprotox - general 1
10) Confidence 0.47 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 17960590 Disease Relevance 0.17 Pain Relevance 0.27
Cigarette smoking and nicotine reduce the level of circulating epidermal growth factor (EGF) and decrease the secretion of EGF from the salivary gland, which are necessary for gastric mucosal cell renewal.
Positive_regulation (circulating) of epidermal growth factor in salivary gland associated with nicotine addiction and nicotine
11) Confidence 0.42 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 14619984 Disease Relevance 1.38 Pain Relevance 0.52
Cigarette smoking and nicotine reduce the level of circulating epidermal growth factor (EGF) and decrease the secretion of EGF from the salivary gland, which are necessary for gastric mucosal cell renewal.
Positive_regulation (circulating) of EGF in salivary gland associated with nicotine addiction and nicotine
12) Confidence 0.42 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 14619984 Disease Relevance 1.38 Pain Relevance 0.52
To identify the phosphatase responsible for EGF-induced dephosphorylation of Grb7 in the nucleus, we examined a direct interaction between the SHP-2 (Src homology region 2–containing phosphatase; Keegan and Cooper, 1996) and Grb7 (Fig.
Positive_regulation (responsible) of EGF-induced in nucleus
13) Confidence 0.41 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
Between 1996 and 2002, a total of 68 patients underwent EGF with Collis gastroplasty.
Positive_regulation (underwent) of EGF
14) Confidence 0.40 Published 2004 Journal J. Gastrointest. Surg. Section Abstract Doc Link 14746833 Disease Relevance 0.58 Pain Relevance 0.07
Twenty-seven (40%) had a large paraesophageal hernia, and 20 (30%) had undergone a prior EGF.
Positive_regulation (undergone) of EGF associated with hiatal hernia
15) Confidence 0.40 Published 2004 Journal J. Gastrointest. Surg. Section Abstract Doc Link 14746833 Disease Relevance 0.68 Pain Relevance 0.08
Immunohistochemical studies demonstrated that cells lining dilated gastric glands at the ulcer margin display an enormous increase in expression of EGF, EGFR, and TNF-a at the initial stage (1–7 days) after ulcer induction [7, 13, 15].
Positive_regulation (increase) of EGF in margin associated with ulcers
16) Confidence 0.40 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 1.09 Pain Relevance 0
There was a significant increase in the EGF content in both the ulcer margin and the intact mucosa in subjects treated with nocloprost but not in patients under treatment with ranitidine.
Positive_regulation (increase) of EGF in margin
17) Confidence 0.37 Published 1997 Journal Scand. J. Gastroenterol. Section Body Doc Link 9361169 Disease Relevance 0 Pain Relevance 0
Immunoreactive epidermal growth factor (IR-EGF) was measured by a highly sensitive and specific radioimmunoassay in gastric juice samples obtained during endoscopy from 26 control subjects, 44 patients with duodenal ulcers, and 18 with benign gastric ulcers.
Positive_regulation (measured) of EGF in gastric juice associated with duodenal ulcer and peptic ulcer
18) Confidence 0.34 Published 1990 Journal Am. J. Gastroenterol. Section Abstract Doc Link 2327382 Disease Relevance 0.46 Pain Relevance 0.07
Although these findings suggest a possible role for EGF deficiency in the pathogenesis of peptic ulcer disease, the pathophysiological significance of our results (if any) remains to be elucidated.
Spec (possible) Positive_regulation (role) of EGF associated with peptic ulcer disease and disease
19) Confidence 0.34 Published 1990 Journal Am. J. Gastroenterol. Section Abstract Doc Link 2327382 Disease Relevance 0.77 Pain Relevance 0.17
Immunoreactive epidermal growth factor (IR-EGF) was measured by a highly sensitive and specific radioimmunoassay in gastric juice samples obtained during endoscopy from 26 control subjects, 44 patients with duodenal ulcers, and 18 with benign gastric ulcers.
Positive_regulation (measured) of epidermal growth factor in gastric juice associated with duodenal ulcer and peptic ulcer
20) Confidence 0.34 Published 1990 Journal Am. J. Gastroenterol. Section Abstract Doc Link 2327382 Disease Relevance 0.46 Pain Relevance 0.07

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