INT227759

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 20.36
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Best1) plasma membrane (Best1)
Anatomy Link Frequency
eye 2
hip 2
testes 2
macrophage 1
retina 1
Best1 (Mus musculus)
Best1 - F81C (1)
Pain Link Frequency Relevance Heat
Spinal cord 166 98.48 Very High Very High Very High
Demyelination 170 97.80 Very High Very High Very High
Sciatic nerve 390 96.68 Very High Very High Very High
cytokine 150 85.84 High High
Inflammation 178 80.80 Quite High
alcohol 48 80.20 Quite High
imagery 17 79.44 Quite High
rheumatoid arthritis 70 77.28 Quite High
ischemia 10 75.64 Quite High
Central nervous system 20 50.96 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 306 100.00 Very High Very High Very High
Duchenne Muscular Dystrophy 8 100.00 Very High Very High Very High
Bone Fracture 216 99.92 Very High Very High Very High
Osteoporosis 155 99.80 Very High Very High Very High
Reprotox - General 1 60 99.46 Very High Very High Very High
Breast Cancer 123 99.12 Very High Very High Very High
Obesity 191 98.88 Very High Very High Very High
Paralysis 340 98.36 Very High Very High Very High
Demyelinating Disease 220 97.80 Very High Very High Very High
Age-related Macular Degeneration 100 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S2G), despite the increased expression of VMD2 and IL-10 in the eyes of these animals.
Gene_expression (expression) of VMD2 in eyes
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 0.53 Pain Relevance 0.19
VMD2-IL10 transgenic mice expressed high levels of secreted IL-10 in the retina, and were prone to develop CNV following laser-injury [3].
Gene_expression (expressed) of VMD2 in retina associated with targeted disruption, injury and age-related macular degeneration
2) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 1.72 Pain Relevance 0.08
In conclusion, VMD2-driven transgenic expression of IL-10 results in macrophage recruitment and FasL-mediated demyelination of the sciatic nerve, axonal death, and ultimately paralysis.
Gene_expression (expression) of VMD2-driven in macrophage associated with targeted disruption, demyelination, sciatic nerve, paralysis and death
3) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 1.48 Pain Relevance 0.40
However, subsequent data has shown that human VMD2 is expressed in multiple sites within the human body [7].
Gene_expression (expressed) of VMD2 in body
4) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 0.98 Pain Relevance 0.04
However, the full expression pattern of human VMD2 within murine tissues is unknown.
Gene_expression (expression) of VMD2
5) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 0.77 Pain Relevance 0.12
Based on studies demonstrating high VMD2 expression in the testes, and since IL-10 gene expression was 55,000 fold higher in the testes of Tg+ mice, we sought to determine if increased IL-10 gene expression in the testes of male Tg+ mice may exacerbate development of disease compared to female Tg+ mice.
Gene_expression (expression) of VMD2 in testes associated with disease
6) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 0.40 Pain Relevance 0.12
GeneAtlas analysis reveals that in humans, VMD2 is highly expressed in the nervous system, including the spinal cord and multiple areas of the brain.
Gene_expression (expressed) of VMD2 in brain associated with spinal cord
7) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 0.92 Pain Relevance 0.10
Since human VMD2 was driving murine IL-10 expression in the Tg+ mice, we examined gene expression of murine IL-10 in multiple tissues from Tg+ sick mice compared to normal Tg?
Gene_expression (expression) of VMD2
8) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 0.63 Pain Relevance 0.12
For mice, murine VMD2 appears to be primarily expressed in the eye and testes [8].
Gene_expression (expressed) of VMD2 in testes
9) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 0.81 Pain Relevance 0.12
Here, we h</span>ave rescued the VRAC current in S2 cells abolished by dBest1 RNAi by <span style="background-color:#B0E0E6">expressing dBest1-F81C.
Gene_expression (expressing) of dBest1-F81C (F81C)
10) Confidence 0.25 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571971 Disease Relevance 0.07 Pain Relevance 0
These questions, coupled with the observation that human bestrophin-1 (hBest1) can regulate voltage-gated Ca2+ channels (Rosenthal et al., 2005; Yu et al., 2008), has led to the suggestion that hBest1 is not a Cl?
Neg (not) Gene_expression (is) of hBest1
11) Confidence 0.22 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571971 Disease Relevance 0.24 Pain Relevance 0
VRAC was rescued by overexpressing bestrophin-1 mutants with altered biophysical properties and responsiveness to sulfhydryl reagents.
Gene_expression (overexpressing) of bestrophin-1
12) Confidence 0.20 Published 2008 Journal The Journal of General Physiology Section Abstract Doc Link PMC2571971 Disease Relevance 0.08 Pain Relevance 0
In TROPOS, at three years in the SR group a 5.7% baseline percentage increment in BMD was observed at the femoral neck and 7.1% at the total hip (P = 0.001), compared with the placebo group.22
Gene_expression (group) of BMD in neck
13) Confidence 0.11 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.24 Pain Relevance 0
For mice, murine VMD2 appears to be primarily expressed in the eye and testes [8].
Gene_expression (expressed) of VMD2 in eye
14) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 0.81 Pain Relevance 0.12
In order to obtain information regarding the amount of bone density gain or loss within each group, all data was compared to their respective baseline BMD (Figure 1; CON: 0.051 ± 0.002?
Gene_expression (respective) of BMD
15) Confidence 0.09 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951122 Disease Relevance 0.49 Pain Relevance 0
In order to investigate the effect of ovarian failure on bone integrity, lumbar BMD of aged VCD-treated and ovariectomized mice was evaluated by DXA and ?
Gene_expression (ovariectomized) of BMD associated with reprotox - general 1
16) Confidence 0.09 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951122 Disease Relevance 0.27 Pain Relevance 0
2.0) and the use of bone-targeted treatment in patients with multiple risk factors for fracture regardless of BMD and/or bone loss of more than 4% per year at either the hip or lumbar spine.37

Arthralgias

Gene_expression (regardless) of BMD in spine associated with arthralgia
17) Confidence 0.07 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2690973 Disease Relevance 0.75 Pain Relevance 0.11
Breast cancer patients found to have osteopenia based on BMD results (t score between ?
Gene_expression (results) of BMD associated with breast cancer and osteoporosis
18) Confidence 0.07 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2690973 Disease Relevance 0.79 Pain Relevance 0.05
Treatment for bone loss was recommended in breast cancer patients found to have osteoporosis based on BMD results (t score ?
Gene_expression (results) of BMD associated with breast cancer and osteoporosis
19) Confidence 0.07 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2690973 Disease Relevance 0.78 Pain Relevance 0
In the absence of BMD, hip fracture probabilities were higher in women than in men.
Neg (absence) Gene_expression (absence) of BMD in hip associated with bone fracture
20) Confidence 0.06 Published 2008 Journal Osteoporos Int Section Body Doc Link PMC2267485 Disease Relevance 0.79 Pain Relevance 0.05

General Comments

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