INT227781

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 7.56
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (GON4L) nucleus (GON4L) DNA binding (GON4L)
cytoplasm (GON4L)
Anatomy Link Frequency
blood 1
optic 1
GON4L (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 12 99.80 Very High Very High Very High
ischemia 10 99.60 Very High Very High Very High
Inflammation 10 78.48 Quite High
Serotonin 51 50.00 Quite Low
Migraine 6 9.88 Low Low
sSRI 33 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
local anesthetic 6 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 161 100.00 Very High Very High Very High
Optic Disorders 79 100.00 Very High Very High Very High
Reperfusion Injury 33 99.98 Very High Very High Very High
Demyelinating Disease 12 99.80 Very High Very High Very High
Cv Unclassified Under Development 13 99.60 Very High Very High Very High
Glaucoma 132 99.20 Very High Very High Very High
Disease 22 99.12 Very High Very High Very High
Infarction 9 95.96 Very High Very High Very High
Pressure Volume 2 Under Development 12 94.64 High High
Cancer 1 78.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBF is, however, also reduced in a number of other diseases as for example in multiple sclerosis [18], (due to a high level of circulating endothelin) [15], indicating that ischemia by itself does not induce GON.
Neg (not) Positive_regulation (induce) of GON associated with multiple sclerosis, ischemia, disease and optic disorders
1) Confidence 0.13 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267728 Disease Relevance 2.04 Pain Relevance 0.22
Reperfusion injury inducing glaucomatous optic neuropathy (GON)
Positive_regulation (inducing) of GON in optic associated with reperfusion injury and optic disorders
2) Confidence 0.13 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267728 Disease Relevance 1.72 Pain Relevance 0.07
While on the one hand, glaucoma patients have reduced OBF and this OBF reduction even has a predictive power for the progression of GON [60], on the other hand, a blood flow reduction by artherosclerosis, multiple sclerosis or by a high level of endothelin-1 (e.g., multiple sclerosis), do not increase the risk for GON significantly.
Neg (not) Positive_regulation (increase) of GON in blood associated with multiple sclerosis, glaucoma and optic disorders
3) Confidence 0.09 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267728 Disease Relevance 2.24 Pain Relevance 0.22
In angle-closure glaucoma, as well as in congenital and secondary glaucomas, the cause/effect relationship between increased IOP and GON is clearly comprehensible.
Positive_regulation (increased) of GON associated with glaucoma, ocular hypertension and optic disorders
4) Confidence 0.04 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701282 Disease Relevance 1.56 Pain Relevance 0.04

General Comments

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