INT227795

Context Info Confidence 0.21 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 5 Disease Relevance 3.05 Pain Relevance 0.21

mitochondrion (Acsl1) endoplasmic reticulum (Acsl1) plasma membrane (Acsl1) peroxisome (Acsl1) ligase activity (Acsl1) lipid metabolic process (Acsl1)

Anatomy Link Frequency urine 2 nucleus 1 Acsl1 (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate 3 83.52 cINOD 10 68.80 diclofenac 1 68.24 tolerance 1 44.60 agonist 1 34.32 Inflammation 7 5.00 cva 7 5.00 fibrosis 4 5.00 cytokine 3 5.00 anesthesia 3 5.00

Disease Link Frequency Relevance Heat Acute Coronary Syndrome 44 100.00 Sprains And Strains 282 99.16 Coronary Artery Disease 56 99.04 Urinary Tract Infection 234 97.24 Infection 127 92.12 Cystitis 60 76.88 Hypertrophy 3 73.96 Coronary Heart Disease 1 72.20 Myocardial Infarction 12 68.08 Dyslipidemia / Combined Dyslipidemia 2 65.32

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In detail, when the ACS, CHD and control groups were compared with respect to eNOS T-786C genotypes, the CC genotype frequency was found to be the most prevalent in ACS group in comparison to CHD and control groups (p = 0.001).

Negative_regulation (prevalent) of ACS associated with acute coronary syndrome and coronary artery disease

1) Confidence 0.21 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2267783 Disease Relevance 1.74 Pain Relevance 0

This is further supported by ibuprofen suppression of other PPAR-related genes, such as ACS and FABP3 (Figure 3); the latter of these two genes encodes fatty acid binding protein 3, which is involved in transporting PPAR ligands to the nucleus [35].

Negative_regulation (suppression) of ACS in nucleus

2) Confidence 0.12 Published 2008 Journal Genome Biol Section Body Doc Link PMC2374704 Disease Relevance 0 Pain Relevance 0.10

The gene encoding acetyl-CoA synthetase, acs, was one of the most strongly downregulated genes in all E. coli strains during growth in urine from women with UTI as compared to culture in urine ex vivo (Table 3).

Negative_regulation (downregulated) of acetyl-CoA synthetase in urine associated with sprains and strains and urinary tract infection

3) Confidence 0.09 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2978726 Disease Relevance 0.45 Pain Relevance 0.04

By qPCR, acs was downregulated nearly 600-fold in vivo, while ackA was relatively unchanged (Fig. 1B).

Negative_regulation (downregulated) of acs

4) Confidence 0.09 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2978726 Disease Relevance 0.36 Pain Relevance 0.03

The gene encoding acetyl-CoA synthetase, acs, was one of the most strongly downregulated genes in all E. coli strains during growth in urine from women with UTI as compared to culture in urine ex vivo (Table 3).

Negative_regulation (downregulated) of acs in urine associated with sprains and strains and urinary tract infection

5) Confidence 0.09 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2978726 Disease Relevance 0.44 Pain Relevance 0.04

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