INT2278

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Context Info
Confidence 0.62
First Reported 1976
Last Reported 2010
Negated 14
Speculated 10
Reported most in Abstract
Documents 81
Total Number 92
Disease Relevance 16.93
Pain Relevance 30.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast) extracellular region (Gast)
Anatomy Link Frequency
stomach 18
neurons 14
neural 10
plasma 8
parietal cell 8
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 233 100.00 Very High Very High Very High
narcan 94 100.00 Very High Very High Very High
antagonist 50 100.00 Very High Very High Very High
Cholecystokinin 48 100.00 Very High Very High Very High
Endogenous opioid 39 100.00 Very High Very High Very High
qutenza 38 100.00 Very High Very High Very High
tetrodotoxin 33 100.00 Very High Very High Very High
Calcitonin gene-related peptide 30 100.00 Very High Very High Very High
gABA 26 100.00 Very High Very High Very High
opiate 25 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ulcers 92 100.00 Very High Very High Very High
Duodenal Ulcer 38 100.00 Very High Very High Very High
Infection 21 100.00 Very High Very High Very High
Immunization 12 100.00 Very High Very High Very High
INFLAMMATION 8 100.00 Very High Very High Very High
Rheumatoid Arthritis 3 99.84 Very High Very High Very High
Peptic Ulcer 2 99.80 Very High Very High Very High
Disease 43 99.32 Very High Very High Very High
Gastritis 17 99.08 Very High Very High Very High
Pulmonary Disease 2 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that activated gastrin release, unlike basal gastrin release, is highly dependent on a neural input: 1) Vagal excitation has a transient stimulating effect on the G cells.
Regulation (dependent) of Localization (release) of gastrin in neural
1) Confidence 0.62 Published 2010 Journal Regul. Pept. Section Abstract Doc Link 20085791 Disease Relevance 0 Pain Relevance 0.26
We conclude that activated gastrin release, unlike basal gastrin release, is highly dependent on a neural input: 1) Vagal excitation has a transient stimulating effect on the G cells.
Regulation (dependent) of Localization (release) of gastrin in neural
2) Confidence 0.62 Published 2010 Journal Regul. Pept. Section Abstract Doc Link 20085791 Disease Relevance 0 Pain Relevance 0.25
Blockade of opiate receptors by naloxone had no effect on vagal gastrin release, however, the noncholinergic gastrin response was reduced significantly by naloxone, suggesting that cholinergic mechanisms normally restrain activation of endogenous opioids during vagal stimulation.
Neg (no) Regulation (effect) of Localization (release) of gastrin associated with endogenous opioid, narcan and opiate
3) Confidence 0.62 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3614557 Disease Relevance 0 Pain Relevance 0.82
Phenylephrine and clonidine did not alter basal gastrin release.
Neg (not) Regulation (alter) of Localization (release) of gastrin associated with clonidine
4) Confidence 0.62 Published 1988 Journal Peptides Section Abstract Doc Link 3420006 Disease Relevance 0 Pain Relevance 0.24
This raises the possibility that endogenous opioids modulate gastrin release.
Regulation (modulate) of Localization (release) of gastrin associated with endogenous opioid
5) Confidence 0.62 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3614557 Disease Relevance 0 Pain Relevance 0.34
In conclusion a major role of endogenous opioids in the regulation of vagal gastrin release can not be detected.
Regulation (role) of Localization (release) of gastrin associated with endogenous opioid
6) Confidence 0.62 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3614557 Disease Relevance 0 Pain Relevance 0.72
Acid-sensitive and alkaline-sensitive sensory neurons regulate pH dependent gastrin secretion in rat.
Regulation (regulate) of Localization (secretion) of gastrin in sensory neurons associated with qutenza
7) Confidence 0.62 Published 2000 Journal Dig. Dis. Sci. Section Title Doc Link 10877240 Disease Relevance 0 Pain Relevance 0.73
The results are in accord with a model for the regulation of gastrin secretion by intramural cholinergic and noncholinergic neurons.
Regulation (regulation) of Localization (secretion) of gastrin in neurons
8) Confidence 0.62 Published 1984 Journal Gastroenterology Section Abstract Doc Link 6146551 Disease Relevance 0 Pain Relevance 0.28
Tetrodotoxin did not affect bombesin-elicited gastrin release, confirming that bombesin-stimulated gastrin release was directly mediated.
Neg (not) Regulation (affect) of Localization (release) of gastrin associated with tetrodotoxin
9) Confidence 0.61 Published 1990 Journal Gastroenterology Section Abstract Doc Link 1976561 Disease Relevance 0 Pain Relevance 0.86
Neural regulation of gastrin and somatostatin secretion in rat gastric antral mucosa.
Regulation (regulation) of Localization (secretion) of gastrin in Neural associated with somatostatin
10) Confidence 0.61 Published 1987 Journal Am. J. Physiol. Section Title Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.37
A muscle-stripped mucosal sheet obtained from rat antrum was mounted in an Ussing chamber and used to examine the regulation of gastrin and somatostatin secretion by antral neurons.
Spec (examine) Regulation (regulation) of Spec (examine) Localization (secretion) of gastrin in muscle associated with somatostatin
11) Confidence 0.61 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.22
Nine patients with chronic obstructive pulmonary disease were given oral aminophylline, intravenous aminophylline, and various inhaled and oral adrenergic bronchodilators to determine the effect of these agents on gastric acid secretion and gastrin release.
Spec (determine) Regulation (effect) of Localization (release) of gastrin associated with pulmonary disease
12) Confidence 0.61 Published 1979 Journal JAMA Section Abstract Doc Link 439357 Disease Relevance 0.21 Pain Relevance 0.08
The effect of 15(R)-15-methyl prostaglandin E2 on meal-stimulated gastric acid secretion, serum gastrin, and pancreatic polypeptide in duodenal ulcer patients.
Regulation (effect) of Localization (secretion) of gastrin associated with duodenal ulcer
13) Confidence 0.61 Published 1979 Journal Dig. Dis. Sci. Section Title Doc Link 456224 Disease Relevance 0.19 Pain Relevance 0.07
Effects of indomethacin on intragastric pH and meal-stimulated serum gastrin secretion in rheumatoid arthritis patients.
Regulation (Effects) of Localization (secretion) of gastrin associated with rheumatoid arthritis
14) Confidence 0.61 Published 1993 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 8218753 Disease Relevance 1.21 Pain Relevance 0.52
The slight increase in plasma gastrin concentration following proximal gastric vagotomy despite a lesser reduction in intragastric acidity may be the result of additional effects on gastrin release by the vagotomy.
Regulation (effects) of Localization (release) of gastrin in plasma
15) Confidence 0.61 Published 1990 Journal Gastroenterology Section Abstract Doc Link 2227275 Disease Relevance 0.24 Pain Relevance 0.06
This review highlights some recent advances in the field by outlining gastrin biosynthesis, summarizing current understanding of gastrin receptors, describing the regulation of gastrin release, and discussing the clinical implications of gastrin in the pathogenesis of peptic ulcer disease.
Regulation (regulation) of Localization (release) of gastrin associated with peptic ulcer disease and disease
16) Confidence 0.61 Published 1997 Journal Annu. Rev. Physiol. Section Abstract Doc Link 9074765 Disease Relevance 0.32 Pain Relevance 0.16
However little is known on the influence of immunization regimes on gastrin release.
Regulation (influence) of Localization (release) of gastrin associated with immunization
17) Confidence 0.60 Published 1999 Journal Eur. J. Med. Res. Section Abstract Doc Link 10425267 Disease Relevance 1.03 Pain Relevance 0.09
Effect of immunization on gastrin release in rat antrum mucosa.
Regulation (Effect) of Localization (release) of gastrin associated with immunization
18) Confidence 0.60 Published 1999 Journal Eur. J. Med. Res. Section Title Doc Link 10425267 Disease Relevance 1.06 Pain Relevance 0.09
In order to investigate the role of peripheral GABA-B receptors, the effects of the putative GABA-B agonist baclofen on immunoreactive gastrin release from an isolated vascularly perfused rat stomach preparation were examined.
Spec (examined) Regulation (effects) of Localization (release) of gastrin in stomach associated with gaba and agonist
19) Confidence 0.60 Published 1989 Journal Experientia Section Abstract Doc Link 2547646 Disease Relevance 0 Pain Relevance 0.56
These studies did not take into consideration the influence of Helicobacter pylori (H. pylori) infection on gastrin release.
Regulation (influence) of Localization (release) of gastrin associated with ulcers and infection
20) Confidence 0.59 Published 2001 Journal Ann Saudi Med Section Abstract Doc Link 17264580 Disease Relevance 0.89 Pain Relevance 0.53

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