INT22781

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Context Info
Confidence 0.48
First Reported 1989
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 76
Total Number 84
Disease Relevance 41.59
Pain Relevance 6.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL7A1) cell adhesion (COL7A1)
Anatomy Link Frequency
extracellular matrix 7
cornea 7
joint 3
stroma 2
myocardium 1
COL7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 203 100.00 Very High Very High Very High
metalloproteinase 31 99.76 Very High Very High Very High
ischemia 3 99.20 Very High Very High Very High
Osteoarthritis 539 99.12 Very High Very High Very High
corticosteroid 67 99.12 Very High Very High Very High
rheumatoid arthritis 7 98.40 Very High Very High Very High
Arthritis 27 97.84 Very High Very High Very High
IPN 5 97.54 Very High Very High Very High
anesthesia 71 97.20 Very High Very High Very High
adenocard 1 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 271 100.00 Very High Very High Very High
Aging 82 100.00 Very High Very High Very High
Keloid Scars 32 100.00 Very High Very High Very High
Rotator Cuff Tears 5 100.00 Very High Very High Very High
Hypersensitivity Vasculitis 1 100.00 Very High Very High Very High
Collagen Disease 1 100.00 Very High Very High Very High
Pulmonary Disease 9 99.98 Very High Very High Very High
Pathologic Dilatation 315 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 17 99.96 Very High Very High Very High
Disease 335 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in collagen cross-linking in degenerative disc disease and scoliosis.
collagen Binding (cross) of associated with scoliosis and disease
1) Confidence 0.48 Published 1998 Journal Spine Section Title Doc Link 9854753 Disease Relevance 0.20 Pain Relevance 0.09
Additional case reports describe diffuse lamellar keratitis (Kymionis et al 2007a) and a reactivation of herpetic keratitis (Kymionis et al 2007b) following collagen cross-linking.
collagen Binding (cross) of associated with herpes simplex virus infection and keratitis
2) Confidence 0.47 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699818 Disease Relevance 0.56 Pain Relevance 0
INTRODUCTION: Although vitamin C is essential for the formation of collagen and proteoglycan and has been shown to minimise surgically induced arthritis in guinea pigs, no controlled trial has examined its effect on human osteoarthritis.
collagen Binding (formation) of associated with osteoarthritis and arthritis
3) Confidence 0.47 Published 2003 Journal Ugeskr. Laeg. Section Abstract Doc Link 12854267 Disease Relevance 0.34 Pain Relevance 0.21
Samples were acid hydrolyzed and the collagen cross-links analyzed by either fractionation on an amino acid analyzer configured for cross-link analysis using ninhydrin postcolumn detection or fractionation by high-pressure liquid chromatography with fluorescence detection.
collagen Spec (analyzed) Binding (cross-links) of
4) Confidence 0.37 Published 1998 Journal Spine Section Body Doc Link 9854753 Disease Relevance 0.15 Pain Relevance 0
The stability of the collagenous components and hence the mechanical integrity of connective tissues such as the disc is dependent on the degree and type of cross-links between the collagen molecules.
collagen Binding (cross-links) of in connective tissues
5) Confidence 0.37 Published 1998 Journal Spine Section Body Doc Link 9854753 Disease Relevance 0.20 Pain Relevance 0
Our studies show that the glycation of human corneal and scleral collagen produces increases in the collagen intermolecular spacing-these increases are similar to those we previously reported on the ageing of collagen in these tissues.
collagen Binding (ageing) of associated with aging
6) Confidence 0.37 Published 1996 Journal Age Ageing Section Abstract Doc Link 8831872 Disease Relevance 0.71 Pain Relevance 0.12
While it may halt progression of corneal ectasia, collagen cross-linking does not in itself affect corneal curvature, and thus may require the use of other means, such as intrastromal corneal rings (Ertan and Colin 2007) or rigid contact lenses (Garcia-Lledo et al 2006) to correct refractive errors (Tan and Por 2007).
collagen Binding (cross) of in lenses associated with refractive errors and pathologic dilatation
7) Confidence 0.36 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699818 Disease Relevance 0.55 Pain Relevance 0
Changes in collagen cross-linking in degenerative disc disease and scoliosis.
collagen Binding (linking) of associated with scoliosis and disease
8) Confidence 0.36 Published 1998 Journal Spine Section Title Doc Link 9854753 Disease Relevance 0.20 Pain Relevance 0.09
Collagen cross-linking provides us for the first time with a minimally invasive approach to addressing the underlying pathology in corneal ectasia, halting its progression, and possibly even improving visual acuity.
Collagen Binding (linking) of associated with pathologic dilatation
9) Confidence 0.35 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699818 Disease Relevance 0.51 Pain Relevance 0
Our personal experience with collagen cross-linking includes 70 patients treated during the past 2 years.
collagen Binding (cross) of
10) Confidence 0.35 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699818 Disease Relevance 0.30 Pain Relevance 0
Though collagen cross-linking is a minimally invasive method, recent reports have indicated possible adverse effects.
collagen Binding (linking) of
11) Confidence 0.35 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699818 Disease Relevance 0.53 Pain Relevance 0
These tests showed that collagen cross-linking by glutaraldehyde, Karnovsky’s solution, or riboflavin-UV irradiation increased the rigidity of the treated corneas compared with controls (Spoerl et al 1998; Spoerl and Seiler 1999).
collagen Binding (-) of in corneas
12) Confidence 0.35 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699818 Disease Relevance 0.65 Pain Relevance 0.10
Studies in both animal models and human patients indicate that collagen cross-linking results in an increase in corneal stiffness and improvement of visual acuity.
collagen Binding (linking) of
13) Confidence 0.35 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699818 Disease Relevance 0.38 Pain Relevance 0
Our personal experience with collagen cross-linking includes 70 patients treated during the past 2 years.
collagen Binding (linking) of
14) Confidence 0.35 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699818 Disease Relevance 0.30 Pain Relevance 0
In a prospective study, Wollensak and colleagues (2003a, 2003c) performed collagen cross-linking on 22 moderate to severe keratoconus patients.
collagen Binding (cross-linking) of associated with corneal disease
15) Confidence 0.35 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699818 Disease Relevance 0.45 Pain Relevance 0
Studies in both animal models and human patients indicate that collagen cross-linking results in an increase in corneal stiffness and improvement of visual acuity.
collagen Binding (-) of
16) Confidence 0.35 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699818 Disease Relevance 0.38 Pain Relevance 0
Collagen cross-linking, a new, minimally invasive method, aims to strengthen the stroma by inducing cross links between neighboring collagen fibers.
Collagen Binding (linking) of in stroma
17) Confidence 0.35 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2699818 Disease Relevance 0.24 Pain Relevance 0
Though collagen cross-linking is a minimally invasive method, recent reports have indicated possible adverse effects.
collagen Binding (cross) of
18) Confidence 0.35 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699818 Disease Relevance 0.53 Pain Relevance 0
Collagen cross-linking: Strengthening the unstable cornea

Corneal ectasia, a weakening of corneal integrity, occurs both due to acquired and congenital conditions such as keratoconus.

Collagen Binding (linking) of in cornea associated with corneal disease and pathologic dilatation
19) Confidence 0.35 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Title Doc Link PMC2699818 Disease Relevance 0.26 Pain Relevance 0
Collagen cross-linking provides us for the first time with a minimally invasive approach to addressing the underlying pathology in corneal ectasia, halting its progression, and possibly even improving visual acuity.
Collagen Binding (cross) of associated with pathologic dilatation
20) Confidence 0.35 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699818 Disease Relevance 0.51 Pain Relevance 0

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