INT227836

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.27
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ERCC6) Golgi apparatus (GPER) endoplasmic reticulum (GPER)
DNA binding (ERCC6) signal transducer activity (GPER) nucleolus (ERCC6)
ERCC6 (Homo sapiens)
GPER (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 10 77.60 Quite High
anesthesia 10 5.00 Very Low Very Low Very Low
Glutamate 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cockayne Syndrome 275 69.12 Quite High
Neurodegenerative Disease 5 67.44 Quite High
Contagious Ecthyma 30 39.12 Quite Low
Repression 5 34.16 Quite Low
Freckles 10 32.12 Quite Low
Syndrome 15 29.40 Quite Low
Disease 20 19.20 Low Low
Aging 10 8.80 Low Low
Hutchinson-gilford Progeria Syndrome 20 5.00 Very Low Very Low Very Low
Infection 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, recruitment of CSB or CSB-associated factors to MER85 elements by the CSB-PGBD3 fusion protein, perhaps in combination with independently transcribed PGBD3 transposase (Figures 1 and 4), may not only inhibit PGBD-mediated transposition, but also transcription of neighboring genes.
CSB Binding (recruitment) of MER85
1) Confidence 0.21 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0.14 Pain Relevance 0.04
Moreover, if the PGBD3 domain of the fusion protein targets CSB-dependent chromatin remodeling complexes to MER85 elements, loss of CSB might affect regulation of MER85-associated genes (Tables S4, S5, S6, S7) or enable MER85 elements themselves to sequester chromatin remodeling factors.


CSB-dependent Binding (complexes) of MER85
2) Confidence 0.16 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0 Pain Relevance 0
Thus, recruitment of CSB or CSB-associated factors to MER85 elements by the CSB-PGBD3 fusion protein, perhaps in combination with independently transcribed PGBD3 transposase (Figures 1 and 4), may not only inhibit PGBD-mediated transposition, but also transcription of neighboring genes.
CSB-associated Binding (recruitment) of MER85
3) Confidence 0.16 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0.14 Pain Relevance 0.04
Moreover, if the PGBD3 domain of the fusion protein targets CSB-dependent chromatin remodeling complexes to MER85 elements, loss of CSB might affect regulation of MER85-associated genes (Tables S4, S5, S6, S7) or enable MER85 elements themselves to sequester chromatin remodeling factors.


CSB-dependent Binding (complexes) of MER85
4) Confidence 0.16 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0 Pain Relevance 0
Surprisingly, many of the CSB-repressed genes are associated with MER85 elements (Table S5, “csb_reliable_up” database list).
CSB-repressed Binding (associated) of MER85
5) Confidence 0.12 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0 Pain Relevance 0

General Comments

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