INT227838

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.23
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ERCC6) nucleolus (ERCC6) nucleus (ERCC6)
DNA binding (ERCC6)
ERCC6 (Homo sapiens)
PGBD3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 95.20 Very High Very High Very High
Genomic Instability 2 74.84 Quite High
Infection 6 55.36 Quite High
Freckles 4 33.84 Quite Low
Syndrome 6 31.12 Quite Low
Cockayne Syndrome 110 28.04 Quite Low
Disease 8 20.92 Low Low
Contagious Ecthyma 12 5.00 Very Low Very Low Very Low
Hutchinson-gilford Progeria Syndrome 8 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, if the PGBD3 domain of the fusion protein targets CSB-dependent chromatin remodeling complexes to MER85 elements, loss of CSB might affect regulation of MER85-associated genes (Tables S4, S5, S6, S7) or enable MER85 elements themselves to sequester chromatin remodeling factors.


CSB-dependent Binding (complexes) of PGBD3
1) Confidence 0.40 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0 Pain Relevance 0
CSB binds to several TFIIH subunits including XPD [17], suggesting a possible role for the N-terminal CSB domain of the CSB-PGBD3 fusion protein in silencing PGBD3 family elements.


CSB Binding (binds) of PGBD3
2) Confidence 0.35 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0.23 Pain Relevance 0

General Comments

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