INT22784

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Context Info
Confidence 0.20
First Reported 1990
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.11
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Serpina1c)
Serpina1c (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 47 85.40 High High
glial activation 1 84.96 Quite High
nMDA receptor 5 84.44 Quite High
Percutaneous transluminal coronary angioplasty 4 81.04 Quite High
antagonist 1 70.00 Quite High
long-term potentiation 12 67.04 Quite High
Angina 4 56.84 Quite High
metalloproteinase 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 17 90.64 High High
Cv Unclassified Under Development 35 85.40 High High
Apoptosis 10 85.28 High High
Injury 18 83.92 Quite High
Coronary Artery Disease 13 80.48 Quite High
Stress 2 70.04 Quite High
Targeted Disruption 9 61.12 Quite High
Cv General 3 Under Development 4 56.84 Quite High
Myocardial Reperfusion Injury 1 30.80 Quite Low
Death 4 14.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Downstream signals after receptor activation include Shc, Crk and phospholipase C, and activation of phosphatidylinositol-3 (PI3) kinase.
Positive_regulation (activation) of PI3
1) Confidence 0.20 Published 2003 Journal Crit Care Section Body Doc Link PMC374373 Disease Relevance 0.55 Pain Relevance 0.11
ApoE receptor ligands also promote other intraneuronal signals via apoE receptors, including PI3 activation, ERK activation, and JNK inhibition [86,96,97] but exactly which receptors promote which signals is unknown.
Positive_regulation (activation) of PI3
2) Confidence 0.13 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.06 Pain Relevance 0.19
Nisoldipine also significantly increased arterial 6KPGF1 alpha at peak exercise.
Positive_regulation (increased) of 6KPGF1 alpha
3) Confidence 0.01 Published 1990 Journal Nippon Ika Daigaku Zasshi Section Abstract Doc Link 2329180 Disease Relevance 0.49 Pain Relevance 0.31

General Comments

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