INT22785

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Context Info
Confidence 0.57
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 5.09
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PRNP) endoplasmic reticulum (PRNP) nucleolus (PRNP)
plasma membrane (PRNP) nucleus (PRNP) cell cycle (PRNP)
Anatomy Link Frequency
plasma 2
nails 1
cartilage 1
dentate nucleus 1
brachial artery 1
PRNP (Homo sapiens)
Pain Link Frequency Relevance Heat
Perioperative pain 1 100.00 Very High Very High Very High
Serotonin 2 98.82 Very High Very High Very High
Hippocampus 9 95.68 Very High Very High Very High
Spinal cord 6 94.40 High High
antagonist 4 93.92 High High
Thalamus 7 90.92 High High
Pain 10 85.28 High High
Angina 6 85.04 High High
Central nervous system 13 83.88 Quite High
ischemia 7 82.72 Quite High
Disease Link Frequency Relevance Heat
Post Operative Pain 1 100.00 Very High Very High Very High
Creutzfeldt Jakob Disease 231 99.70 Very High Very High Very High
Gliosis 9 99.46 Very High Very High Very High
Death 111 99.20 Very High Very High Very High
Disease 105 97.96 Very High Very High Very High
Lifespan 2 97.88 Very High Very High Very High
Cryptococcus Infection 1 97.52 Very High Very High Very High
Candida Infection 1 96.16 Very High Very High Very High
Targeted Disruption 119 95.96 Very High Very High Very High
Drug Induced Neurotoxicity 8 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It significantly decreased brachial artery pressure, pressure rate product (PRP), mean coronary sinus pressure and coronary vascular resistance both at rest and peak exercise.
Negative_regulation (decreased) of PRP in brachial artery
1) Confidence 0.57 Published 1990 Journal Nippon Ika Daigaku Zasshi Section Abstract Doc Link 2329180 Disease Relevance 0.49 Pain Relevance 0.31
A reduction in TXB2 levels in PRP was also observed, but reached statistical significance (P less than 0.01) only for AA-induced TXB2 generation.
Negative_regulation (reduction) of PRP in PRP
2) Confidence 0.57 Published 1983 Journal Z Kardiol Section Abstract Doc Link 6666233 Disease Relevance 0.08 Pain Relevance 0.12
These findings demonstrate that acute loss of PrPC in neurones in adulthood is tolerated, and that the neuropathophysiology of prion diseases is not due to loss of PrPC function [142,143].
Negative_regulation (loss) of PrPC associated with creutzfeldt jakob disease
3) Confidence 0.43 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.65 Pain Relevance 0.11
Other grey matter structures such as the cerebellar dentate nucleus and the olive in the brain stem showed little spongiosis, but a very strong gliosis and a diffuse and intense deposition of PrP (figure 3e–h).
Negative_regulation (deposition) of PrP in dentate nucleus associated with gliosis
4) Confidence 0.43 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581659 Disease Relevance 0.19 Pain Relevance 0.28
Serotonin-induced platelet aggregation in dog platelet-rich plasma (PRP) in vitro was most potently inhibited by ketanserin (IC50 0.55 x 10(-8) M), followed by nexopamil (IC50) 0.81 x 10(-7) M) and gallopamil (IC50 1.76 x 10(-6) M).
Negative_regulation (inhibited) of PRP in plasma associated with serotonin
5) Confidence 0.41 Published 1993 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 7506319 Disease Relevance 0.38 Pain Relevance 0.34
OBJECTIVES/HYPOTHESIS: To determine if placement of autologous platelet-rich plasma (PRP) on the tonsil beds at the time of tonsillectomy would decrease postoperative pain and complications.
Negative_regulation (decrease) of PRP in tonsil associated with perioperative pain
6) Confidence 0.41 Published 2008 Journal Laryngoscope Section Abstract Doc Link 18622315 Disease Relevance 0.10 Pain Relevance 0.10
These findings demonstrate that acute loss of PrPC in neurones in adulthood is tolerated, and that the neuropathophysiology of prion diseases is not due to loss of PrPC function [142,143].
Negative_regulation (loss) of PrPC associated with creutzfeldt jakob disease
7) Confidence 0.37 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.59 Pain Relevance 0.11
Surprisingly, despite the in vitro premises and the positive theoretical assumptions, the results of this study showed not only the lack of a positive effect but even a negative influence of autologous PRP on bone and cartilage regeneration.
Negative_regulation (influence) of PRP in cartilage
8) Confidence 0.31 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2954989 Disease Relevance 0.05 Pain Relevance 0
Our findings suggest that C3H mice propagate sCJD prions at a level insufficient for sustaining the disease upon serial passage.
Negative_regulation (propagate) of sCJD associated with disease
9) Confidence 0.29 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1383487 Disease Relevance 0.86 Pain Relevance 0
l; after centrifugation the mean number of PLTs in the PRP was 874 ± 87 × 103/?
Negative_regulation (/) of PRP in PLTs
10) Confidence 0.27 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2954989 Disease Relevance 0 Pain Relevance 0
PRP is easy to produce with minimal effort [14,18] and can be prepared as needed at the point of care [16].
Negative_regulation (prepared) of PRP
11) Confidence 0.23 Published 2010 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2844688 Disease Relevance 0.53 Pain Relevance 0.07
In the present paper combined treatment of long bone non-unions by expandable self locking nails and PRP gel is evaluated.
Negative_regulation (locking) of PRP in nails
12) Confidence 0.22 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2656988 Disease Relevance 0.33 Pain Relevance 0.09
Furthermore, turning off a VS or CS medical device because of a rapidly progressing fatal illness from which death is imminent may be psychologically different from a situation lacking such an illness.
Negative_regulation (progressing) of fatal associated with death
13) Confidence 0.02 Published 2010 Journal BMC Med Ethics Section Body Doc Link PMC2949779 Disease Relevance 0.84 Pain Relevance 0.03

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