INT227903

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.56
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TNF, ADAMTS5) intracellular (TNF) extracellular matrix organization (TNF)
extracellular space (TNF) signal transduction (TNF) peptidase activity (ADAMTS5)
Anatomy Link Frequency
chondrocytes 2
TNF (Homo sapiens)
ADAMTS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 37 99.60 Very High Very High Very High
cytokine 2 97.96 Very High Very High Very High
metalloproteinase 9 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Tendonitis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Knee Osteoarthritis 36 99.60 Very High Very High Very High
Injury 2 95.92 Very High Very High Very High
Osteoarthritis 12 75.36 Quite High
Shock 5 50.00 Quite Low
Necrosis 2 50.00 Quite Low
Cancer 1 50.00 Quite Low
Frailty 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Tendinopathy 1 5.00 Very Low Very Low Very Low
Pseudarthrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNF-alpha activates MMP and aggrecanase production by chondrocytes [14,15] and cooperates with other cytokines to degrade cartilage matrix [16].
TNF-alpha Positive_regulation (activates) of Gene_expression (production) of aggrecanase in chondrocytes associated with cytokine
1) Confidence 0.01 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.56 Pain Relevance 0.24

General Comments

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