INT227904

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNFRSF1A, TNF) extracellular region (TNFRSF1A, TNF) plasma membrane (TNFRSF1A, TNF)
signal transduction (TNF) intracellular (TNF) nucleus (TNFRSF1A)
Anatomy Link Frequency
articular 1
TNFRSF1A (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 9 87.24 High High
Osteoarthritis 37 77.64 Quite High
cytokine 2 73.72 Quite High
Tendonitis 1 12.36 Low Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 12 94.76 High High
Knee Osteoarthritis 36 77.64 Quite High
Apoptosis 1 71.28 Quite High
Shock 5 50.00 Quite Low
Necrosis 2 50.00 Quite Low
Cancer 1 50.00 Quite Low
Injury 2 35.64 Quite Low
Frailty 2 16.64 Low Low
Pseudarthrosis 1 14.08 Low Low
Tendinopathy 1 12.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The biological activities of TNF-alpha are regulated by two specific cell-surface receptors TNF-R55 and TNF-R75; the former is mainly involved in signal transduction in articular tissue cells and its expression is up-regulated on osteoarthritic chondrocytes and synoviocytes, that in turn show an increased sensitivity to TNF-alpha [6,7].
TNF-R55 Regulation (regulated) of TNF-alpha in articular associated with osteoarthritis
1) Confidence 0.01 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.41 Pain Relevance 0.36

General Comments

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