INT227921

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.65
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MMRN1) cell adhesion (MMRN1)
Anatomy Link Frequency
chondrocyte 4
MMRN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 74 98.14 Very High Very High Very High
metalloproteinase 18 96.12 Very High Very High Very High
cytokine 4 83.76 Quite High
Tendonitis 2 68.32 Quite High
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Knee Osteoarthritis 72 98.14 Very High Very High Very High
Apoptosis 2 94.32 High High
Injury 4 91.60 High High
Pseudarthrosis 2 70.04 Quite High
Necrosis 4 69.24 Quite High
Tendinopathy 2 68.32 Quite High
Fasciitis 2 67.40 Quite High
Osteoarthritis 24 60.96 Quite High
Urinary Calculi 2 55.84 Quite High
Shock 10 53.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In OA, beta1 integrin expression is significantly reduced in damaged cartilage [5] and this would alter chondrocyte/ECM interactions and disrupt beta1 integrin/GFr synergy leading to activation of catabolic pathways, increase of MMPs expression and induction of chondrocyte apoptosis.
Regulation (alter) of ECM Binding (interactions) of in chondrocyte associated with metalloproteinase, apoptosis and osteoarthritis
1) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.62 Pain Relevance 0.49
These chondrocyte/ECM interactions are regulated by a large family of transmembrane glycoproteins whereby beta1 integrins are the most widely expressed and interact with several matrix proteins such as collagen, fibronectin, vitronectin and laminin [4].
Regulation (regulated) of ECM Binding (interactions) of in chondrocyte
2) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 1.03 Pain Relevance 0.46

General Comments

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