INT227925

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.19
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB1) plasma membrane (ITGB1)
Anatomy Link Frequency
chondrocyte 4
cartilage 2
ITGB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 111 99.96 Very High Very High Very High
metalloproteinase 27 93.12 High High
cytokine 6 77.76 Quite High
Tendonitis 3 52.12 Quite High
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Knee Osteoarthritis 108 99.96 Very High Very High Very High
Osteoarthritis 36 94.40 High High
Apoptosis 3 91.32 High High
Injury 6 83.28 Quite High
Pseudarthrosis 3 53.84 Quite High
Necrosis 6 53.04 Quite High
Tendinopathy 3 52.12 Quite High
Fasciitis 3 51.20 Quite High
Shock 15 50.00 Quite Low
Cancer 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data confirmed that OA chondrocyte phenotype is defined by reduced beta1 integrin expression and increased TNF-alpha and IL-10 levels, as earlier reported [10-12].
Negative_regulation (reduced) of Gene_expression (expression) of beta1 integrin in chondrocyte associated with osteoarthritis
1) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.69 Pain Relevance 0.29
The decrease in beta1 integrin cell surface expression seems to be an early event in OA pathogenesis and critical in breaking down the complex ECM/chondrocyte interactions that maintain cartilage homeostasis [3].
Negative_regulation (decrease) of Gene_expression (expression) of beta1 integrin in cartilage associated with osteoarthritis
2) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.70 Pain Relevance 0.30
In OA, beta1 integrin expression is significantly reduced in damaged cartilage [5] and this would alter chondrocyte/ECM interactions and disrupt beta1 integrin/GFr synergy leading to activation of catabolic pathways, increase of MMPs expression and induction of chondrocyte apoptosis.
Negative_regulation (reduced) of Gene_expression (expression) of beta1 integrin in chondrocyte associated with metalloproteinase, apoptosis and osteoarthritis
3) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.79 Pain Relevance 0.53

General Comments

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