INT22794

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Context Info
Confidence 0.02
First Reported 1990
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.14
Pain Relevance 7.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tail 1
Body 1
Gt(pU21)50Imeg (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 6 100.00 Very High Very High Very High
Antinociceptive 13 99.98 Very High Very High Very High
Enkephalin 4 99.90 Very High Very High Very High
Opioid 12 99.88 Very High Very High Very High
Oxycodone 16 99.60 Very High Very High Very High
tolerance 10 98.78 Very High Very High Very High
antagonist 11 98.56 Very High Very High Very High
tail-flick 9 98.30 Very High Very High Very High
narcan 8 97.92 Very High Very High Very High
antinociception 17 94.00 High High
Disease Link Frequency Relevance Heat
Pain 1 74.48 Quite High
Opiate Addiction 1 61.72 Quite High
Anxiety Disorder 1 46.16 Quite Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An administration of opioids that act on the different subtype receptors morphine, U50 and SNC80, induced a dose dependent decrease in both the rearing and climbing activity, meaning no behavioral dissociation.
Regulation (act) of U50 associated with opioid and morphine
1) Confidence 0.02 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16574254 Disease Relevance 0.06 Pain Relevance 1.11
The Isc response of U50,488H, however, was neither blocked nor reversed by naloxone or ICI 174,864, nor blocked by norbinaltorphimine, suggesting that the response was not mediated via opioid receptors.
Regulation (response) of U50 associated with narcan and opioid receptor
2) Confidence 0.02 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2329501 Disease Relevance 0 Pain Relevance 0.58
Body temperature decreased with DAMGO, SNC80, U50,488H, and oxycodone; tolerance did not develop to hypothermic effect and BMS182874 did not affect DAMGO, SNC80, U50,488H, or oxycodone induced changes in body temperature.
Neg (not) Regulation (affect) of U50 in Body associated with oxycodone and tolerance
3) Confidence 0.01 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20303944 Disease Relevance 0 Pain Relevance 2.38
Antinociceptive response of DAMGO, SNC80, U50,488H, and oxycodone in tolerant mice treated with BMS182874 was significantly higher (44.55%, 37.48%, 43.02%, and 56.08%, respectively) compared to tolerant mice treated with vehicle.
Regulation (response) of U50 associated with oxycodone and antinociceptive
4) Confidence 0.01 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20303944 Disease Relevance 0 Pain Relevance 2.32
However, the tail-flick inhibition induced by [D-Ala2]deltorphin II, [D-Ala2,NMePhe4,Gly5-ol]enkephalin and U50,488H were not affected by (-)TAN-67 pretreatment.
Neg (not) Regulation (affected) of U50 in tail associated with tail-flick and enkephalin
5) Confidence 0.01 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9023269 Disease Relevance 0.07 Pain Relevance 1.07

General Comments

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