INT227949

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.23
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm2) plasma membrane (Chrm2) signal transducer activity (Chrm2)
Anatomy Link Frequency
T cells 2
follicular B cells 1
Chrm2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 110 93.80 High High
Central nervous system 10 90.56 High High
midbrain 5 89.64 High High
dopamine receptor 40 84.96 Quite High
antagonist 20 70.96 Quite High
opiate 15 54.08 Quite High
Potency 17 50.00 Quite Low
Morphine 10 49.20 Quite Low
addiction 10 48.48 Quite Low
Nucleus accumbens 5 47.80 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 315 100.00 Very High Very High Very High
Cognitive Disorder 20 99.90 Very High Very High Very High
Infection 103 99.44 Very High Very High Very High
Psychosis 5 80.60 Quite High
Epstein-barr Virus 54 72.64 Quite High
Sprains And Strains 25 63.12 Quite High
Viral Infection 5 60.40 Quite High
Morphine Dependence 5 49.20 Quite Low
Aggression 10 18.24 Low Low
Lymphatic System Cancer 28 6.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that the loss of M2 during MHV68 infection specifically enhanced the MHV68-specific CD8+ T cell response, despite a significant decrease in viral latency and reactivation (see Figure 6D).
Negative_regulation (loss) of M2 in T cell associated with infection
1) Confidence 0.25 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.23 Pain Relevance 0
Hippocampal acetylcholine neurotransmission was dysregulated and cognition was impaired in M2, M4 and M2/M4 muscarinic receptor knockout mice [50].
Negative_regulation (impaired) of M2 associated with targeted disruption and cognitive disorder
2) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 1.03 Pain Relevance 0.14
In M2 KO mice, USVs were lost in about 70–80% of the mice, correlating with a loss of sexual interaction.
Negative_regulation (lost) of M2 associated with targeted disruption
3) Confidence 0.22 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2268741 Disease Relevance 0.49 Pain Relevance 0.04
In this study, we found the USV quality was still excellent in M2, M4, M5 muscarinic and the D2 receptors KO mice, implying that motor control in the KO mice is not defective.
Negative_regulation (excellent) of M2 associated with targeted disruption
4) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.34 Pain Relevance 0.12
Hippocampal acetylcholine neurotransmission was dysregulated and cognition was impaired in M2, M4 and M2/M4 muscarinic receptor knockout mice [50].
Negative_regulation (impaired) of M2 associated with targeted disruption and cognitive disorder
5) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 1.04 Pain Relevance 0.15
The dramatic reduction of USVs in M2 and M5 KO mice during male-female interactions suggested that both M2 and M5 receptors were crucial for USVs associated with male-female interactions.
Negative_regulation (reduction) of M2 associated with targeted disruption
6) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.28 Pain Relevance 0.24
One is a highly potent M2 receptor-mediated inhibition of forskolin- and ?
Negative_regulation (inhibition) of M2
7) Confidence 0.19 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0.37 Pain Relevance 0.04
We have previously shown that loss of M2 leads to increased levels of virus-specific CD8+ T cells, as assessed using tetramers to two distinct viral epitopes (ORF6486–498 and ORF61524–531) expressed during MHV68 replication [30].
Negative_regulation (loss) of M2 in T cells
8) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.21 Pain Relevance 0
However, the M2 null virus was diminished in marginal zone B cells and elevated in follicular B cells compared to wild type MHV68 (Fig. 2D).
Negative_regulation (diminished) of M2 in follicular B cells
9) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.24 Pain Relevance 0

General Comments

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