INT227952

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 15
Disease Relevance 5.19
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm2) plasma membrane (Chrm2) signal transducer activity (Chrm2)
Anatomy Link Frequency
ileum 2
smooth muscle 1
bladder 1
Chrm2 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 4 90.08 High High
dopamine receptor 8 82.40 Quite High
Eae 1 58.24 Quite High
Dopamine 22 53.68 Quite High
Potency 66 50.00 Quite Low
agonist 45 43.64 Quite Low
cytokine 44 41.88 Quite Low
antagonist 80 39.28 Quite Low
anesthesia 33 29.04 Quite Low
chemokine 2 6.00 Low Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 189 96.20 Very High Very High Very High
Sprains And Strains 160 95.68 Very High Very High Very High
Immunization 147 94.76 High High
Weight Loss 42 91.92 High High
Targeted Disruption 303 91.72 High High
Lymphopenia 14 88.00 High High
Fever 21 86.56 High High
Infection 196 85.36 High High
Body Weight 61 84.28 Quite High
Viral Infection 4 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both cholinergic and dopaminergic systems are involved in the USVs elicited during male-female interactions, with M2 and M5 muscarinic receptors particularly important in the induction.
M2 Binding (interactions) of
1) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.30 Pain Relevance 0.15
Thus, the M3 antagonism profile of standard muscarinic contractions of the ileum and bladder is not inconsistent with the postulate that both M2 and M3 receptors interact to elicit contraction.
M2 Binding (interact) of in bladder
2) Confidence 0.17 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0.22 Pain Relevance 0.03
Finally, the M2 receptor inhibits adenylate cyclase in smooth muscle.
M2 Binding (receptor) of in smooth muscle
3) Confidence 0.17 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0 Pain Relevance 0.05
Lysates were pre-cleared with pre-immune chicken IgY, and M2 precipitated with chicken anti-M2 IgY followed by capture by agarose anti-IgY beads (Aves Labs, Inc.).
M2 Binding (precipitated) of
4) Confidence 0.16 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0 Pain Relevance 0
Consistent with this hypothesis, M2 has been shown to interact with a number of cellular proteins in vitro.
M2 Binding (interact) of
5) Confidence 0.15 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.26 Pain Relevance 0
These results implicate a role for M2 in modulating immunoglobulin isotype class switching.


M2 Binding (role) of
6) Confidence 0.15 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.40 Pain Relevance 0
These results are summarized in Table 3 and are consistent with the postulate mentioned above that the muscarinic contractile response in the mouse ileum includes major and minor, directly acting M3 and M2 components, respectively.
M2 Binding (acting) of in ileum
7) Confidence 0.14 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0.59 Pain Relevance 0
Thus, the M3 antagonism profile of standard muscarinic contractions of the ileum and bladder is not inconsistent with the postulate that both M2 and M3 receptors interact to elicit contraction.
M2 Binding (interact) of in ileum
8) Confidence 0.06 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0.22 Pain Relevance 0.03
Despite showing no neutralizing antibody responses, mice immunized with HA+NP+M2 were fully protected against lethal challenge.
M2 Binding (immunized) of
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.85 Pain Relevance 0
Comparative efficacy of DNA/rAd5 vaccination with different combinations of HA, NP and M2 in ferrets
M2 Binding (combinations) of
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.41 Pain Relevance 0
Significant anti-M2 humoral responses were detected in animals immunized with NP+M2 post-rAd boost (p?
M2 Binding (immunized) of
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.23 Pain Relevance 0
We then assessed the ability of NP and M2, alone or in combination, to protect ferrets against a high challenge dose of lethal H5N1 virus, when delivered in a triple DNA prime, rAd5 boost regimen.
M2 Binding (ability) of
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.34 Pain Relevance 0
Ferrets were immunized with HA alone, NP alone, M2 alone, NP+M2, HA+NP+M2, and control using gene-based vaccines delivered in DNA/rAd5 vectors.
M2 Binding (immunized) of
13) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.72 Pain Relevance 0
We compared these groups to ferrets immunized with HA alone or in combination with NP+M2.


M2 Binding (combination) of
14) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.28 Pain Relevance 0
Studies in mice have shown that M2 antibodies may help to reduce viral replication [8], [9], [52], [53], while studies in ferrets have shown M2 to be associated with reductions in viral recovery [20], [54].
M2 Binding (associated) of
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.37 Pain Relevance 0

General Comments

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