INT227971

Context Info Confidence 0.06 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.66 Pain Relevance 0

Gm2404 (Mus musculus)

Pain Link Frequency Relevance Heat Pain 3 5.00 imagery 3 5.00

Disease Link Frequency Relevance Heat Mycobacterial Infection 8 93.44 Buruli Ulcer 139 85.48 Sprains And Strains 27 71.12 Lyme Disease 12 63.44 Ulcers 4 61.20 Bites And Stings 24 59.08 Infection 61 53.48 Disease 80 50.00 Francisella Infection 6 35.40 Heart Rate Under Development 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Genomic analysis suggests that M. ulcerans evolved from an M. marinum-like ancestor [21], [51] through the acquisition of a large virulence plasmid and accumulation of multiple copies of insertion sequences, IS2404 and IS2606.

Positive_regulation (accumulation) of IS2404

1) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3001905 Disease Relevance 0.16 Pain Relevance 0

In 1999, Portaels et al reported detection of IS2404 positive PCR from two groups of predaceous aquatic insects, Naucoridae and Belostomatidae [15].

Positive_regulation (positive) of IS2404

2) Confidence 0.03 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2268743 Disease Relevance 0.49 Pain Relevance 0

IS2404 PCR has been widely used for detection of M. ulcerans in the environment and patients because of the high copy number of the IS element (213) within the M. ulcerans genome [28] However, evidence from the M. ulcerans genome as well as results from restriction fragment length polymorphisms of IS2404 suggests considerable heterogeneity between copies, as well as the presence of incomplete copies which could lead to production of multiple products [29].

Positive_regulation (used) of IS2404

3) Confidence 0.03 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2268743 Disease Relevance 0 Pain Relevance 0

General Comments

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