INT227971

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.66
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Gm2404 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 8 93.44 High High
Buruli Ulcer 139 85.48 High High
Sprains And Strains 27 71.12 Quite High
Lyme Disease 12 63.44 Quite High
Ulcers 4 61.20 Quite High
Bites And Stings 24 59.08 Quite High
Infection 61 53.48 Quite High
Disease 80 50.00 Quite Low
Francisella Infection 6 35.40 Quite Low
Heart Rate Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genomic analysis suggests that M. ulcerans evolved from an M. marinum-like ancestor [21], [51] through the acquisition of a large virulence plasmid and accumulation of multiple copies of insertion sequences, IS2404 and IS2606.
Positive_regulation (accumulation) of IS2404
1) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3001905 Disease Relevance 0.16 Pain Relevance 0
In 1999, Portaels et al reported detection of IS2404 positive PCR from two groups of predaceous aquatic insects, Naucoridae and Belostomatidae [15].
Positive_regulation (positive) of IS2404
2) Confidence 0.03 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2268743 Disease Relevance 0.49 Pain Relevance 0
IS2404 PCR has been widely used for detection of M. ulcerans in the environment and patients because of the high copy number of the IS element (213) within the M. ulcerans genome [28] However, evidence from the M. ulcerans genome as well as results from restriction fragment length polymorphisms of IS2404 suggests considerable heterogeneity between copies, as well as the presence of incomplete copies which could lead to production of multiple products [29].
Positive_regulation (used) of IS2404
3) Confidence 0.03 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2268743 Disease Relevance 0 Pain Relevance 0

General Comments

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