INT227973

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
bands 1
Gm2404 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 10 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Buruli Ulcer 363 96.12 Very High Very High Very High
Lyme Disease 54 90.16 High High
Bites And Stings 45 90.04 High High
Laboratory Infection 9 86.32 High High
Disease 136 84.92 Quite High
Ulcers 11 84.00 Quite High
Infection 117 80.20 Quite High
Sprains And Strains 90 67.28 Quite High
Francisella Infection 13 62.12 Quite High
Death 1 59.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A major breakthrough in environmental studies occurred with the development of the first PCR probes for M. ulcerans based on detection of IS2404 by Ross et al. [63].
Gene_expression (detection) of IS2404
1) Confidence 0.10 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3001905 Disease Relevance 0.45 Pain Relevance 0
Early work showed that IS2404 was present in M. ulcerans, but absent in the closely related mycobacterial species M. marinum, and over 40 other mycobacterial species suggesting that the insertion sequence was specific for M. ulcerans [11].
Neg (absent) Gene_expression (absent) of IS2404
2) Confidence 0.05 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2268743 Disease Relevance 0.98 Pain Relevance 0
In 1999, Portaels et al reported detection of IS2404 positive PCR from two groups of predaceous aquatic insects, Naucoridae and Belostomatidae [15].
Gene_expression (detection) of IS2404
3) Confidence 0.05 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2268743 Disease Relevance 0.49 Pain Relevance 0
Early work showed that IS2404 was present in M. ulcerans, but absent in the closely related mycobacterial species M. marinum, and over 40 other mycobacterial species suggesting that the insertion sequence was specific for M. ulcerans [11].
Neg (absent) Gene_expression (present) of IS2404
4) Confidence 0.05 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2268743 Disease Relevance 0.98 Pain Relevance 0
Preliminary evidence for M. ulcerans in environmental samples was obtained from PCR detection of the insertion sequence IS2404 [10] along with PCR detection of the enoyl reductase (ER) domain of the mycolactone toxin [26].
Gene_expression (detection) of IS2404
5) Confidence 0.04 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2268743 Disease Relevance 0.06 Pain Relevance 0
In this study 319 invertebrate and vertebrate samples were analyzed using IS2404 PCR and the PCR products were sequenced.
Spec (analyzed) Gene_expression (using) of IS2404
6) Confidence 0.03 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2268743 Disease Relevance 0 Pain Relevance 0
In 2004, Marsollier et al obtained IS2404 positive PCR results from 5/80 Naucoridae collected in Cote d'Ivoire and, more importantly, successfully cultured an IS2404 positive mycobacteria from two of these.
Gene_expression (positive) of IS2404
7) Confidence 0.03 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2268743 Disease Relevance 0.31 Pain Relevance 0
None of the IS2404 PCR-positive insects identified in West Africa are blood feeders, making it unlikely that they could play a major role in transmission.
Neg (None) Gene_expression (None) of IS2404 in blood
8) Confidence 0.03 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2268743 Disease Relevance 0.26 Pain Relevance 0
Experimental results confirm this theory since others have found no difference between the use of IS2404 PCR and that of 16sRNA PCR for detection of M. ulcerans in human samples despite the enormous difference in copy number [34] and results from VNTR analysis of clinical isolates show gel bands with an intensity never reported for IS2404 PCR [23] .
Gene_expression (use) of IS2404 in bands
9) Confidence 0.03 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2268743 Disease Relevance 0 Pain Relevance 0
In Australia, IS2404 has been detected in water as well as from detritus collected from water bodies and, most recently, from trapped mosquitoes [12],[13],[14].
Gene_expression (detected) of IS2404
10) Confidence 0.03 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2268743 Disease Relevance 0.67 Pain Relevance 0

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