INT22798

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Context Info
Confidence 0.60
First Reported 1990
Last Reported 2010
Negated 7
Speculated 2
Reported most in Abstract
Documents 64
Total Number 66
Disease Relevance 26.71
Pain Relevance 8.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Shbg) extracellular region (Shbg)
Anatomy Link Frequency
blood 5
plasma 4
nerve 1
brain 1
autonomic 1
Shbg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 31 100.00 Very High Very High Very High
transcutaneous nerve stimulation 1 100.00 Very High Very High Very High
Migraine 26 99.66 Very High Very High Very High
Neurotransmitter 2 99.52 Very High Very High Very High
Fibrositis 86 99.24 Very High Very High Very High
Enkephalin 3 98.86 Very High Very High Very High
methadone 1 98.74 Very High Very High Very High
Face pain 1 98.20 Very High Very High Very High
Lasting pain 5 96.92 Very High Very High Very High
Catecholamine 12 94.64 High High
Disease Link Frequency Relevance Heat
Peritonitis 240 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 134 100.00 Very High Very High Very High
Reprotox - General 3 25 100.00 Very High Very High Very High
Bradycardia 18 100.00 Very High Very High Very High
Reprotox - General 2 4 100.00 Very High Very High Very High
Obesity 110 99.96 Very High Very High Very High
Headache 80 99.66 Very High Very High Very High
Endometriosis (extended) 42 99.52 Very High Very High Very High
Myocardial Infarction 60 99.46 Very High Very High Very High
Middle Cerebral Artery Infarction 14 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the fundamental differences between levonorgestrel and the 3 new gonanes, the absence of the androgenic effect reveals the predominant estrogenic effect on HDL cholesterol and sex hormone binding globulin (SHBG).
Regulation (effect) of SHBG associated with disorder of lipid metabolism
1) Confidence 0.60 Published 1993 Journal Contracept Fertil Sex (Paris) Section Abstract Doc Link 12318228 Disease Relevance 0.22 Pain Relevance 0.06
Among the fundamental differences between levonorgestrel and the 3 new gonanes, the absence of the androgenic effect reveals the predominant estrogenic effect on HDL cholesterol and sex hormone binding globulin (SHBG).
Regulation (effect) of sex hormone binding globulin associated with disorder of lipid metabolism
2) Confidence 0.60 Published 1993 Journal Contracept Fertil Sex (Paris) Section Abstract Doc Link 12318228 Disease Relevance 0.22 Pain Relevance 0.06
Results indicate that inhibition of nitric oxide (NO) might be responsible in part for the elevation of ABP, and the degree of the elevation would be dependent on the degree of contribution of NO to the regulation of ABP.
Regulation (regulation) of ABP
3) Confidence 0.53 Published 1995 Journal Artif Organs Section Abstract Doc Link 7763190 Disease Relevance 0 Pain Relevance 0
A mechanism of age-associated alterations in plasma sex hormone levels as well as their effect on drug metabolizing enzyme activities were studied using male and female Fischer 344 rats of ages ranging between 3 and 30 months.
Regulation (alterations) of sex hormone in plasma
4) Confidence 0.44 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2329519 Disease Relevance 0.07 Pain Relevance 0
The SHBG concentration did not change throughout the entire study.
Neg (not) Regulation (change) of SHBG
5) Confidence 0.43 Published 2000 Journal J Clin Pharmacol Section Abstract Doc Link 10709161 Disease Relevance 0 Pain Relevance 0
Altered sexual function has been reported in individuals addicted to opioids or on methadone maintenance, yet little literature is available regarding the effect of intraspinal opioids on libido or sex hormone levels.
Regulation (effect) of sex hormone associated with reprotox - general 3, methadone and opioid
6) Confidence 0.41 Published 1994 Journal J Pain Symptom Manage Section Abstract Doc Link 7517429 Disease Relevance 0.19 Pain Relevance 0.54
The Gram-negative aerobic bacteria are the major responsible for SBP episodes and Gram-positive bacteria, mainly Staphylococcus aureus, are being considered an emergent agent causing SBP.
Regulation (responsible) of SBP associated with peritonitis
7) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2621420 Disease Relevance 1.03 Pain Relevance 0
Other antibiotics have been studied and are an alternative for SBP treatment, but caution should be taken in avoidance of those that have nephrotoxicity and increased risk of multiresistant bacteria development.
Regulation (alternative) of SBP associated with nephrotoxicity and peritonitis
8) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621420 Disease Relevance 0.91 Pain Relevance 0
Once the bacteria reach the ascitic fluid, the host immune defense is responsible for the occurrence or not of SBP.
Regulation (responsible) of SBP associated with peritonitis
9) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621420 Disease Relevance 0.65 Pain Relevance 0.03
More recently, a study within a US medical care program in 2002 to 2003 showed even higher rates of therapy initiation or intensification: 64% of patients with insufficiently controlled SBP levels and 47% for insufficiently controlled LDL cholesterol levels [22].
Regulation (controlled) of SBP
10) Confidence 0.34 Published 2007 Journal Cardiovasc Diabetol Section Body Doc Link PMC2034374 Disease Relevance 0.74 Pain Relevance 0
The American trial did not show these changes overall, although when analyzed according to menopausal status there was a decrease in FSH and LH levels, and an increase in SHBG level in post-menopausal women.
Regulation (increase) of SHBG associated with endometriosis (extended)
11) Confidence 0.34 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 0.55 Pain Relevance 0.10
A mechanism of age-associated alterations in plasma sex hormone levels as well as their effect on drug metabolizing enzyme activities were studied using male and female Fischer 344 rats of ages ranging between 3 and 30 months.
Regulation (effect) of sex hormone in plasma
12) Confidence 0.32 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2329519 Disease Relevance 0.07 Pain Relevance 0.05
In subjects with symptoms of vagal blockade, HRV, SBP and SBRS were significantly affected by bilateral SGB.
Regulation (affected) of SBP
13) Confidence 0.32 Published 2009 Journal Circ. J. Section Body Doc Link 19713654 Disease Relevance 0 Pain Relevance 0
These results were consistent with the hypothesis that the Vi/Vc-vl transition region plays a unique role in deep craniofacial pain processing and may integrate autonomic and opioid-related modulatory signals in a manner dependent on sex hormone status.
Regulation (dependent) of sex hormone in autonomic associated with face pain and opioid
14) Confidence 0.27 Published 2002 Journal Pain Section Abstract Doc Link 11932076 Disease Relevance 0.52 Pain Relevance 1.02
As a result, its overall androgenic potential is in part dependent on the progesterone it is combined with, and the progesterone effect on SHBG.
Regulation (dependent) of SHBG
15) Confidence 0.27 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504056 Disease Relevance 0.06 Pain Relevance 0.03
However, there were no significant changes in SBP-LF in control rats.
Neg (no) Regulation (changes) of SBP-LF
16) Confidence 0.26 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004820 Disease Relevance 0.38 Pain Relevance 0.11
Migraine in some women is associated with changes in sex hormone levels.
Regulation (changes) of sex hormone associated with migraine
17) Confidence 0.24 Published 2007 Journal Expert Opin Pharmacother Section Abstract Doc Link 17685879 Disease Relevance 0.70 Pain Relevance 0.92
In conclusion, opioids exert important effects on plasma and CNS sex hormone levels.
Regulation (effects) of CNS sex hormone in plasma associated with opioid
18) Confidence 0.24 Published 2006 Journal Neuroscience Section Abstract Doc Link 16580783 Disease Relevance 0 Pain Relevance 0.99
Changes in the RR interval (RRI), systolic blood pressure (SBP), HRV, SBPV and SBRS were assessed before and after bilateral SGB.
Regulation (Changes) of SBP in blood
19) Confidence 0.23 Published 2009 Journal Circ. J. Section Body Doc Link 19713654 Disease Relevance 0 Pain Relevance 0
The maximal values of SBP, HR and RPP during the observation (from the beginning of intravenous anesthetic induction to 5 minutes after intubation) were significantly higher than their preinduction values (P < 0.05).
Regulation (values) of SBP
20) Confidence 0.23 Published 2005 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 16447644 Disease Relevance 0 Pain Relevance 0

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