INT2280

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Context Info
Confidence 0.43
First Reported 1979
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 70
Total Number 72
Disease Relevance 69.43
Pain Relevance 8.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TNFAIP1) nucleolus (TNFAIP1) nucleus (TNFAIP1)
embryo development (TNFAIP1) cytoplasm (TNFAIP1)
Anatomy Link Frequency
B12 61
tendon 2
spinal cord 2
ileum 1
tongue 1
TNFAIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 2 99.80 Very High Very High Very High
Paresthesia 88 99.64 Very High Very High Very High
imagery 142 99.44 Very High Very High Very High
anesthesia 23 99.32 Very High Very High Very High
Spinal cord 29 99.30 Very High Very High Very High
depression 504 98.92 Very High Very High Very High
peripheral neuropathy 45 98.72 Very High Very High Very High
nud 17 97.00 Very High Very High Very High
antiepileptic Drug 22 96.88 Very High Very High Very High
Chronic pancreatitis 113 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Congenital Anomalies 138 99.92 Very High Very High Very High
Epilepsy 16 99.92 Very High Very High Very High
Megaloblastic Anemia 54 99.84 Very High Very High Very High
Mycobacterial Infection 441 99.80 Very High Very High Very High
Anaemia 123 99.80 Very High Very High Very High
Increased Venous Pressure Under Development 5 99.80 Very High Very High Very High
Cv Unclassified Under Development 2 99.80 Very High Very High Very High
Neuropathy 50 99.78 Very High Very High Very High
Dysesthesia 142 99.64 Very High Very High Very High
Cancer 131 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vitamin B12 deficiency may be a frequent and treatable cause of neurological dysfunction in patients with HIV infection.
Negative_regulation (deficiency) of B12 in B12 associated with anesthesia, acquired immune deficiency syndrome or hiv infection and infection
1) Confidence 0.43 Published 1991 Journal Arch. Neurol. Section Abstract Doc Link 1848071 Disease Relevance 0.80 Pain Relevance 0.22
The preoperative recognition of B12 deficiency and N2O-induced neurological deterioration in patients with B12 deficiency is reviewed.
Negative_regulation (deficiency) of B12 in B12
2) Confidence 0.38 Published 1990 Journal J. Neurosurg. Section Abstract Doc Link 2157826 Disease Relevance 0.08 Pain Relevance 0.18
Selected neuropathological results suggest a relationship between vitamin B12 deficiency and vacuolar myelopathy.
Negative_regulation (deficiency) of B12 in B12 associated with spinal cord diseases
3) Confidence 0.38 Published 1991 Journal Arch. Neurol. Section Abstract Doc Link 1848071 Disease Relevance 0.62 Pain Relevance 0.21
An increased prevalence of vitamin B12 deficiency has been reported in patients infected by the human immunodeficiency virus (HIV).
Negative_regulation (deficiency) of B12 in B12 associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.38 Published 1991 Journal Arch. Neurol. Section Abstract Doc Link 1848071 Disease Relevance 0.57 Pain Relevance 0.17
B12 is thereby inactivated and this interferes with folate metabolism and thymidine synthesis: the effect may be detected after only a few hours in vivo exposure of mammals to 50% nitrous oxide.
Negative_regulation (inactivated) of B12 in B12
5) Confidence 0.38 Published 1979 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 398128 Disease Relevance 0.09 Pain Relevance 0.31
[A case of alcoholic with vitamin B12 deficiency presenting central pontine and extrapontine myelinolysis on MRI].
Negative_regulation (deficiency) of B12 in B12 associated with central pontine myelinolysis
6) Confidence 0.38 Published 2007 Journal Rinsho Shinkeigaku Section Title Doc Link 17511290 Disease Relevance 0.85 Pain Relevance 0.18
Postoperative myeloneuropathy: a preventable complication in patients with B12 deficiency.
Negative_regulation (deficiency) of B12 in B12
7) Confidence 0.33 Published 1990 Journal J. Neurosurg. Section Title Doc Link 2157826 Disease Relevance 0.09 Pain Relevance 0.17
In each instance, the patient was found to have hematological abnormalities present preoperatively consistent with vitamin B12 deficiency and to have undergone general anesthesia involving N2O.
Negative_regulation (deficiency) of B12 in B12 associated with anesthesia and congenital anomalies
8) Confidence 0.33 Published 1990 Journal J. Neurosurg. Section Abstract Doc Link 2157826 Disease Relevance 0.10 Pain Relevance 0.18
The frequent use of N2O in general anesthesia and the significant incidence of B12 deficiency make it imperative that the surgeon be aware of this complication and its easy prevention.
Negative_regulation (deficiency) of B12 in B12 associated with anesthesia
9) Confidence 0.33 Published 1990 Journal J. Neurosurg. Section Abstract Doc Link 2157826 Disease Relevance 0.09 Pain Relevance 0.19
This caused inactivation of the remaining marginal stores of B12 with resultant neurological decompensation.
Negative_regulation (inactivation) of B12 in B12
10) Confidence 0.33 Published 1990 Journal J. Neurosurg. Section Abstract Doc Link 2157826 Disease Relevance 0.09 Pain Relevance 0.19
The preoperative recognition of B12 deficiency and N2O-induced neurological deterioration in patients with B12 deficiency is reviewed.
Negative_regulation (deficiency) of B12 in B12
11) Confidence 0.33 Published 1990 Journal J. Neurosurg. Section Abstract Doc Link 2157826 Disease Relevance 0.08 Pain Relevance 0.17
180 pmol/L, unlikely to have B12 deficiency).
Negative_regulation (deficiency) of B12 in B12
12) Confidence 0.33 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0 Pain Relevance 0
We administered a questionnaire to patients with B12 deficiency, offered the option of a six-month trial of oral replacement, and administered a follow-up questionnaire.
Negative_regulation (deficiency) of B12 in B12
13) Confidence 0.33 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0 Pain Relevance 0
Another study found that patients become very attached to receiving their injections; after identifying 48 patients who did not meet diagnostic criteria for B12 deficiency and providing educational sessions to encourage discontinuing injections, 38% stated they would leave the practice if denied their injections [22].
Negative_regulation (deficiency) of B12 in B12
14) Confidence 0.33 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0 Pain Relevance 0.03
Therefore, we combined qualitative and quantitative methods to test the hypothesis that patients offered oral B12 are willing to switch to oral therapy and to explore the reasons for their choice.


Negative_regulation (switch) of B12 in B12
15) Confidence 0.33 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0 Pain Relevance 0
Although oral replacement with high doses of vitamin B12 is both effective and safe for the treatment of B12 deficiency, little is known about patients' views concerning the acceptability and effectiveness of oral B12.
Negative_regulation (deficiency) of B12 in B12
16) Confidence 0.33 Published 2005 Journal BMC Fam Pract Section Abstract Doc Link PMC554115 Disease Relevance 0 Pain Relevance 0
However, because approximately 1% of orally ingested B12 is absorbed via simple diffusion throughout the gastrointestinal tract (i.e., independently of intrinsic factor)[1,2], oral replacement with high doses of cobalamin is both effective and safe, regardless of the etiology of B12 deficiency [1,3-12].
Negative_regulation (deficiency) of B12 in B12
17) Confidence 0.33 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0 Pain Relevance 0
We included all patients who received regular injections (i.e., every 1 to 3 months), regardless of age and etiology of B12 deficiency.
Negative_regulation (deficiency) of B12 in B12
18) Confidence 0.33 Published 2005 Journal BMC Fam Pract Section Body Doc Link PMC554115 Disease Relevance 0 Pain Relevance 0
There is no evidence that pharmacological folate will have a deleterious effect on either methylation status or mood, nor that it will lead to sub-acute combined degeneration of the spinal cord or other neurological complications, provided that B12 deficiency is excluded.
Negative_regulation (deficiency) of B12 in B12 associated with spinal cord
19) Confidence 0.28 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2238748 Disease Relevance 0.34 Pain Relevance 0.09
Vitamin B12 deficiency may also cause seizures.
Negative_regulation (deficiency) of B12 in B12 associated with convulsion
20) Confidence 0.26 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2329654 Disease Relevance 1.23 Pain Relevance 0.18

General Comments

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