INT228002

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.57
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Loxl1, Fbln5) extracellular space (Fbln5) oxidoreductase activity (Loxl1)
cell adhesion (Fbln5) proteinaceous extracellular matrix (Loxl1) extracellular matrix organization (Fbln5)
Loxl1 (Mus musculus)
Fbln5 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Exfoliation Syndrome 207 99.14 Very High Very High Very High
Glaucoma 156 88.16 High High
Genetic Predisposition To Disease 9 5.00 Very Low Very Low Very Low
Ocular Hypertension 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Cataract 6 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 6 5.00 Very Low Very Low Very Low
Brain Hemorrhage 3 5.00 Very Low Very Low Very Low
Hypertension 3 5.00 Very Low Very Low Very Low
Coronary Heart Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since LOXL1 interacts with other proteins [30,31] such as fibulin-5 (FBLN5) and elastin (ELN), it is likely that through these protein–protein interactions and their anticipated common biochemical pathways, the effect of such polymorphisms on XFS becomes more significant.
LOXL1 Binding (interacts) of FBLN5 associated with exfoliation syndrome
1) Confidence 0.34 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.52 Pain Relevance 0
Since LOXL1 interacts with other proteins [30,31] such as fibulin-5 (FBLN5) and elastin (ELN), it is likely that through these protein–protein interactions and their anticipated common biochemical pathways, the effect of such polymorphisms on XFS becomes more significant.
LOXL1 Binding (interacts) of fibulin-5 associated with exfoliation syndrome
2) Confidence 0.34 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.52 Pain Relevance 0
There is also a strong linkage disequilibrium between these two SNPs (D’=0.996) thus suggesting that the effect of these two amino acid polymorphisms on XFS is probably influenced by protein–protein interaction of LOXL1 with FBLN5, ELN, or other, unidentified LOXL1-interacting proteins.
LOXL1 Binding (interaction) of FBLN5 associated with exfoliation syndrome
3) Confidence 0.34 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.54 Pain Relevance 0

General Comments

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