INT228017

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 15
Disease Relevance 11.55
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Loxl1) extracellular region (Loxl1) proteinaceous extracellular matrix (Loxl1)
Loxl1 (Mus musculus)
fst (Xenopus laevis)
Pain Term Frequency Confidence Heat
Angina 15 46.32 Quite Low
Disease Term Frequency Confidence Heat
Exfoliation Syndrome 987 100.00 Very High Very High Very High
Glaucoma 720 99.96 Very High Very High Very High
Syndrome 12 95.84 Very High Very High Very High
Disease 51 95.56 Very High Very High Very High
Fibrosis 6 94.44 High High
Genetic Predisposition To Disease 27 84.44 Quite High
Ocular Hypertension 63 79.84 Quite High
Targeted Disruption 6 75.00 Quite High
Optic Disorders 6 72.72 Quite High
Obesity 12 51.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent genome-wide association studies in the Icelandic population identified multiple SNPs from the lysyl oxidase-like 1 (LOXL1) gene that were highly associated with XFS and XFG [19].
lysyl oxidase-like 1 Binding (associated) of XFS associated with exfoliation syndrome and glaucoma
1) Confidence 0.05 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.46 Pain Relevance 0
It is also interesting that LOXL1 polymorphisms are highly associated with both XFS and XFG, but no such association was reported for subjects only affected with primary open-angle glaucoma [19].
LOXL1 Binding (associated) of XFS associated with exfoliation syndrome and glaucoma
2) Confidence 0.05 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.87 Pain Relevance 0
Recent genome-wide association studies in the Icelandic population identified multiple SNPs from the lysyl oxidase-like 1 (LOXL1) gene that were highly associated with XFS and XFG [19].
LOXL1 Binding (associated) of XFS associated with exfoliation syndrome and glaucoma
3) Confidence 0.05 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.45 Pain Relevance 0
In this present study, three major LOXL1 SNPs were found to be significantly associated with XFS/XFG, even though the sample size was as small as 50.
LOXL1 Binding (associated) of XFS associated with exfoliation syndrome and glaucoma
4) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 0.88 Pain Relevance 0
In summary, we confirmed the results that the three SNPs of LOXL1 are associated with XFS/XFG, but the risk alleles at rs1048661 and rs2165241 in this present study are opposite to Caucasian populations.
LOXL1 Binding (associated) of XFS associated with exfoliation syndrome and glaucoma
5) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 0.98 Pain Relevance 0
Identification of specific polymorphisms in LOXL1 that are highly associated with XFS and XFG provide a good starting point for future research into the etiology of this condition.
LOXL1 Binding (associated) of XFS associated with exfoliation syndrome and glaucoma
6) Confidence 0.05 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.50 Pain Relevance 0
Recently, a genome-wide association study in the Icelandic and Swedish populations indicated that three single nucleotide polymorphisms (SNPs) in the lysyl oxidase-like 1 (LOXL1) gene on chromosomal region 15q24 were significantly associated with XFS and XFG [25].
LOXL1 Binding (associated) of XFS associated with exfoliation syndrome and glaucoma
7) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 0.79 Pain Relevance 0
There is also a strong linkage disequilibrium between these two SNPs (D’=0.996) thus suggesting that the effect of these two amino acid polymorphisms on XFS is probably influenced by protein–protein interaction of LOXL1 with FBLN5, ELN, or other, unidentified LOXL1-interacting proteins.
LOXL1-interacting Binding (interaction) of XFS associated with exfoliation syndrome
8) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.56 Pain Relevance 0
All patients were genotyped using the SNaPshot Assay for three SNPs from LOXL1 that were reported to have strong associations with XFS in the Icelandic and Swedish populations [19].
LOXL1 Binding (associations) of XFS associated with exfoliation syndrome
9) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.47 Pain Relevance 0
There is also a strong linkage disequilibrium between these two SNPs (D’=0.996) thus suggesting that the effect of these two amino acid polymorphisms on XFS is probably influenced by protein–protein interaction of LOXL1 with FBLN5, ELN, or other, unidentified LOXL1-interacting proteins.
LOXL1 Binding (interaction) of XFS associated with exfoliation syndrome
10) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.54 Pain Relevance 0
Our study confirmed that the LOXL1 polymorphisms are highly associated with both XFS and XFG patients in the two populations studied.


LOXL1 Binding (associated) of XFS associated with exfoliation syndrome and glaucoma
11) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 1.09 Pain Relevance 0
For the LOXL1 gene, individual alleles of rs1048661 (G), rs3825942 (G), and rs2165241 (T) are highly associated with XFS and XFG in American and European populations.
LOXL1 Binding (associated) of XFS associated with exfoliation syndrome and glaucoma
12) Confidence 0.04 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2268854 Disease Relevance 0.78 Pain Relevance 0
Recently, a genome-wide association study in the Icelandic and Swedish populations indicated that three single nucleotide polymorphisms (SNPs) in the lysyl oxidase-like 1 (LOXL1) gene on chromosomal region 15q24 were significantly associated with XFS and XFG [25].
oxidase-like 1 Binding (associated) of XFS associated with exfoliation syndrome and glaucoma
13) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 0.80 Pain Relevance 0
Therefore, this study was conducted to investigate the association between the LOXL1 variants and XFS in the Chinese population.


LOXL1 Binding (association) of XFS associated with exfoliation syndrome
14) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 1.40 Pain Relevance 0
The association between XFS and the three LOXL1 SNPs has been confirmed in other Caucasian [31–38] and Indian populations [39].
LOXL1 Binding (association) of XFS associated with exfoliation syndrome
15) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 0.96 Pain Relevance 0

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