INT228036

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.10
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cfl1) cytoskeleton (Cfl1) nucleus (Cfl1)
intracellular (Cfl1) cytoskeleton organization (Cfl1) cytoplasm (Cfl1)
Cfl1 (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 70 99.98 Very High Very High Very High
Inflammation 204 99.30 Very High Very High Very High
lidocaine 204 98.56 Very High Very High Very High
Inflammatory response 18 86.76 High High
GABA receptor 2 81.84 Quite High
gABA 2 77.32 Quite High
potassium channel 2 72.20 Quite High
Glutamate 2 69.04 Quite High
cytokine 56 60.24 Quite High
chemokine 30 52.96 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 222 99.30 Very High Very High Very High
Cramps 22 97.36 Very High Very High Very High
Inflammatory Bowel Disease 2 69.20 Quite High
Colitis 2 63.12 Quite High
Disease 10 58.56 Quite High
Sepsis 2 17.60 Low Low
Injury 14 11.56 Low Low
Systemic Inflammatory Response Syndrome 2 10.60 Low Low
Apoptosis 40 5.00 Very Low Very Low Very Low
Peritonitis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present report, we identified specific proteins in inflammatory exudates and cytoskeleton protein cofilin-1 that were reduced by volatile anesthetics and are known to be important in cell migration.
Negative_regulation (reduced) of cofilin-1 associated with inflammation
1) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.64 Pain Relevance 0.58
In addition, isoflurane reduced cofilin-1 (Table 5), a major actin-depolymerization factor regulating actin dynamics and generation and maintenance of cell protrusions, key cellular events that are required for migration [26].
Negative_regulation (reduced) of cofilin-1 associated with isoflurane
2) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.46 Pain Relevance 0.76

General Comments

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