INT228037

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.58
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fpr3) plasma membrane (Fpr3) signal transducer activity (Fpr3)
Fpr3 (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 102 98.40 Very High Very High Very High
Inflammatory response 10 98.20 Very High Very High Very High
Inflammation 114 90.52 High High
COX2 16 85.12 High High
isoflurane 35 5.00 Very Low Very Low Very Low
cytokine 29 5.00 Very Low Very Low Very Low
chemokine 16 5.00 Very Low Very Low Very Low
local anesthetic 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 125 98.02 Very High Very High Very High
Mycobacterial Infection 96 96.00 Very High Very High Very High
Apoptosis 52 95.52 Very High Very High Very High
Infection 62 85.48 High High
Necrosis 55 82.48 Quite High
Death 20 27.60 Quite Low
Cramps 11 5.00 Very Low Very Low Very Low
Sprains And Strains 10 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Peritonitis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, although temporally regulated dampening of the inflammatory response is generally highly beneficial to the host, our studies uncover a novel scenario wherein LXA4-driven reduction of “proinflammatory” PGE2 synthesis functionally acts as an efficient mechanism used by pathogenic Mtb.
Negative_regulation (reduction) of LXA4-driven associated with mycobacterial infection and inflammatory response
1) Confidence 0.20 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.12 Pain Relevance 0.28
Of interest, lidocaine at both doses (0.008% and 0.08%), when added together with LXA4, significantly impaired LXA4-stimulated phagocytosis (Fig. 3C).
Negative_regulation (impaired) of LXA4 associated with lidocaine
2) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.46 Pain Relevance 0.65

General Comments

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