INT228045

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 6.96
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fpr3) plasma membrane (Fpr3) signal transducer activity (Fpr3)
Anatomy Link Frequency
peritoneum 1
immune system 1
Fpr3 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 80 99.44 Very High Very High Very High
Inflammation 162 97.56 Very High Very High Very High
Inflammatory response 14 95.28 Very High Very High Very High
lidocaine 102 88.72 High High
aspirin 4 79.80 Quite High
ischemia 1 42.80 Quite Low
sodium channel 1 25.00 Low Low
local anesthetic 6 20.72 Low Low
cytokine 33 15.68 Low Low
isoflurane 35 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 306 99.80 Very High Very High Very High
Mycobacterial Infection 480 99.72 Very High Very High Very High
Death 100 97.76 Very High Very High Very High
Apoptosis 180 97.72 Very High Very High Very High
Necrosis 271 97.56 Very High Very High Very High
INFLAMMATION 181 97.56 Very High Very High Very High
Sprains And Strains 50 97.28 Very High Very High Very High
Peritonitis 6 96.96 Very High Very High Very High
Htlv Types I And Ii 3 81.24 Quite High
Burns 2 51.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The findings presented in the previous section indicate that infection with virulent Mtb leads to the induction of LXA4 and suppression of PGE2, which results in the necrotic death of infected M?.
Positive_regulation (induction) of LXA4 associated with mycobacterial infection, death and infection
1) Confidence 0.32 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.02 Pain Relevance 0
with H37Rv induces LXA4 and inhibits COX2 and prostanoid production, whereas H37Ra infection fails to induce LXA4 but stimulates COX2 and prostanoid production, led to the hypothesis that H37Rv-induced LXA4 production may foster M?
Positive_regulation (induces) of LXA4 associated with cox2 and infection
2) Confidence 0.23 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.26 Pain Relevance 0.13
with H37Rv induces LXA4 and inhibits COX2 and prostanoid production, whereas H37Ra infection fails to induce LXA4 but stimulates COX2 and prostanoid production, led to the hypothesis that H37Rv-induced LXA4 production may foster M?
Neg (fails) Positive_regulation (induce) of LXA4 associated with cox2 and infection
3) Confidence 0.23 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.26 Pain Relevance 0.13
Thus, the induction of LXA4 and the resulting inhibition of PGE2 production contribute to the virulence of Mtb and enhance its capacity to evade killing by the innate immune system.
Positive_regulation (induction) of LXA4 in immune system associated with mycobacterial infection
4) Confidence 0.21 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.33 Pain Relevance 0.03
As it was observed in vitro, virulent bacteria induced remarkably more LXA4 after 7 d of infection, whereas avirulent H37Ra induced more PGE2.
Positive_regulation (induced) of LXA4 associated with infection
5) Confidence 0.19 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.09 Pain Relevance 0
PGE2, a signal that can activate the full LXA4-biosynthetic capacity in vivo [17], was present in the peritoneum prior to peritonitis and elevated during the acute inflammatory response.
Positive_regulation (activate) of LXA4 in peritoneum associated with inflammatory response and peritonitis
6) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 1.00 Pain Relevance 0.65

General Comments

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