INT228047

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.33
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Tbce) protein folding (Tbce) cytoskeleton (Tbce)
cytoplasm (Tbce)
Anatomy Link Frequency
macrophages 2
Tbce (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 306 99.98 Very High Very High Very High
Inflammation 313 98.68 Very High Very High Very High
aspirin 12 80.28 Quite High
agonist 18 73.92 Quite High
COX-2 inhibitor 3 71.80 Quite High
Inflammatory response 28 60.48 Quite High
Arthritis 1 58.00 Quite High
cytokine 84 52.80 Quite High
chemokine 45 45.60 Quite Low
isoflurane 105 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 60 100.00 Very High Very High Very High
INFLAMMATION 341 98.68 Very High Very High Very High
Cramps 33 90.72 High High
Adult Respiratory Distress Syndrome 88 88.40 High High
Injury 35 77.48 Quite High
Disease 16 68.84 Quite High
Arthritis 1 58.00 Quite High
Diabetic Retinopathy 1 57.00 Quite High
Lung Injury 13 24.88 Low Low
Leukemia 2 5.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A previous study found that the expression of NEP on circulating PMN was reduced in humans challenged with LPS [40].
Negative_regulation (reduced) of Gene_expression (expression) of PMN
1) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.03 Pain Relevance 0.15
Galectin-1 inhibits PMN migration during PMN-endothelial interactions in vitro and in vivo [23].
Negative_regulation (inhibits) of Gene_expression (migration) of PMN
2) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.37 Pain Relevance 0.61
Lidocaine impairs PMN apoptosis and their removal by macrophages
Negative_regulation (impairs) of Gene_expression (apoptosis) of PMN in macrophages associated with apoptosis and lidocaine
3) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.44 Pain Relevance 0.95
At 48 h after zymosan challenge, lidocaine at 0.08% also reduced PMN apoptosis ?
Negative_regulation (reduced) of Gene_expression (apoptosis) of PMN associated with apoptosis and lidocaine
4) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.48 Pain Relevance 0.77

General Comments

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