INT228048

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.47
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Tbce) protein folding (Tbce) cytoskeleton (Tbce)
cytoplasm (Tbce)
Tbce (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 153 99.80 Very High Very High Very High
cytokine 60 99.76 Very High Very High Very High
chemokine 30 99.32 Very High Very High Very High
lidocaine 205 98.86 Very High Very High Very High
Inflammation 215 98.42 Very High Very High Very High
Inflammatory stimuli 1 82.96 Quite High
Inflammatory response 19 76.96 Quite High
Inflammatory mediators 2 71.20 Quite High
isoflurane 70 38.24 Quite Low
Glutamate 2 32.64 Quite Low
Disease Link Frequency Relevance Heat
Infection 14 99.64 Very High Very High Very High
INFLAMMATION 236 98.42 Very High Very High Very High
Disease 11 92.96 High High
Pneumonia 48 88.40 High High
Sepsis 3 84.32 Quite High
Bacterial Infection 7 79.72 Quite High
Targeted Disruption 1 78.32 Quite High
Injury 16 78.28 Quite High
Systemic Inflammatory Response Syndrome 2 77.32 Quite High
Peritonitis 12 70.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Even doses as low as 0.008% (w/v) lidocaine, when given together with zymosan, led to a significant increase in the accumulation of PMN at 24 h (?
Positive_regulation (increase) of Positive_regulation (accumulation) of PMN associated with lidocaine
1) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.20 Pain Relevance 0.68
Thus, changes in the balance between pro- and anti-inflammatory cytokines, rather than individual chemokines or specific cytokines, appear to contribute to the observed increases in PMN numbers obtained at 24 h with lidocaine.
Positive_regulation (contribute) of Positive_regulation (increases) of PMN associated with chemokine, inflammation, lidocaine and cytokine
2) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 1.45 Pain Relevance 1.12
During infection, antigen contact induces PMN activation and MMP release [7].
Positive_regulation (induces) of Positive_regulation (activation) of PMN associated with metalloproteinase and infection
3) Confidence 0.01 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.81 Pain Relevance 0.55

General Comments

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