INT228052

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.56
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Tbce) protein folding (Tbce) cytoskeleton (Tbce)
cytoplasm (Tbce)
Anatomy Link Frequency
PMN 2
Tbce (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 306 99.64 Very High Very High Very High
agonist 18 97.10 Very High Very High Very High
Inflammation 306 90.32 High High
antagonist 6 77.16 Quite High
cytokine 84 36.56 Quite Low
local anesthetic 18 33.12 Quite Low
chemokine 45 29.36 Quite Low
isoflurane 105 22.24 Low Low
Inflammatory response 27 5.00 Very Low Very Low Very Low
aspirin 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 60 100.00 Very High Very High Very High
Cramps 33 99.40 Very High Very High Very High
INFLAMMATION 333 90.32 High High
Peritonitis 18 65.28 Quite High
Cicatrix 3 59.04 Quite High
Abscess 3 58.72 Quite High
Injury 21 56.96 Quite High
Disease 15 52.24 Quite High
Htlv Types I And Ii 9 5.00 Very Low Very Low Very Low
Burns 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the mice treated with both lidocaine and zymosan, the numbers of PMN continued to increase after 12 h and reached a maximum at 24 h.
Positive_regulation (increase) of Negative_regulation (numbers) of PMN associated with lidocaine
1) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.32 Pain Relevance 0.73
Hence resolution agonists have two main mechanisms of actions at the tissue level; they lower the numbers of infiltrating PMN to the inflamed sites and tissues; and they stimulate the active removal of debris and apoptotic PMN from the inflamed sites by non-phlogistic activation of macrophages [5].
Positive_regulation (stimulate) of Negative_regulation (removal) of PMN in PMN associated with agonist and apoptosis
2) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.95 Pain Relevance 0.52
Thus, exudate CRAMP/LL-37 may also contribute to increased PMN numbers obtained at 4 h in lidocaine-treated mice (Fig. 1A).
Positive_regulation (increased) of Negative_regulation (numbers) of PMN associated with cramps and lidocaine
3) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.28 Pain Relevance 0.58

General Comments

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