INT228053

Context Info Confidence 0.15 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.57 Pain Relevance 0.82

Anatomy Link Frequency SH3 2 Sh3 (Mus musculus)

Pain Link Frequency Relevance Heat isoflurane 35 99.78 Inflammation 102 96.60 chemokine 15 87.12 cytokine 28 85.92 lidocaine 102 81.92 local anesthetic 6 6.96 Inflammatory response 9 5.00 agonist 6 5.00 aspirin 4 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Cramps 11 97.88 INFLAMMATION 111 96.60 Apoptosis 20 5.00 Injury 7 5.00 Peritonitis 6 5.00 Disease 5 5.00 Htlv Types I And Ii 3 5.00 Burns 2 5.00 Overdose 1 5.00 Necrosis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

By comparison, isoflurane treatment increased SH3 domain-binding glutamic acid-rich like protein (SH3BGRL), which might have anti-oxidative and anti-inflammatory properties [27], [28].

Positive_regulation (increased) of SH3 Binding (binding) of in SH3 associated with inflammation and isoflurane

1) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.57 Pain Relevance 0.82

General Comments

This test has worked.