INT228061

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.39
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1)
DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)
Anatomy Link Frequency
macrophage 2
brain 2
sinus 1
Th2 cell 1
Hand1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 147 100.00 Very High Very High Very High
Inflammation 118 100.00 Very High Very High Very High
chemokine 16 100.00 Very High Very High Very High
Inflammatory response 22 91.80 High High
cINOD 9 77.28 Quite High
Infliximab 52 50.00 Quite Low
Crohn's disease 1 47.64 Quite Low
corticosteroid 7 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 210 100.00 Very High Very High Very High
INFLAMMATION 141 100.00 Very High Very High Very High
Bacterial Meningitis 7 100.00 Very High Very High Very High
Pneumococcal Infection 10 99.78 Very High Very High Very High
Cancer 79 99.12 Very High Very High Very High
Mycobacterial Infection 147 97.92 Very High Very High Very High
Inflammatory Bowel Disease 82 97.56 Very High Very High Very High
Targeted Disruption 25 94.48 High High
Atherosclerosis 68 94.08 High High
Infection 139 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TH1 cytokine secretion is increased after administration of rAAV-/rAdv-hTERTC27
Positive_regulation (increased) of Localization (secretion) of TH1 associated with cytokine
1) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938346 Disease Relevance 0.33 Pain Relevance 0.24
antibody IgG1 response (PWT and P22W), while others induced an IgG2a response, such as PDM, PFDM and P24M (Figure 8); this can be compared to PWT and PDM with adjuvant vaccine, which induced a significant Th1 response (Figure 9).
Positive_regulation (induced) of Localization (response) of Th1
2) Confidence 0.22 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2270279 Disease Relevance 0.40 Pain Relevance 0.34
Mice primed to mount Th2 cell responses followed by pneumococcal infection showed an increase in the number of Pneumococci and an increase in sinus inflammation than compared to naive or Th1 -primed groups [56].
Positive_regulation (increase) of in Th2 cell Localization (increase) of Th1 in sinus associated with bacterial meningitis, pneumococcal infection and inflammation
3) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.79 Pain Relevance 0.21
Consequently, the release of the Th1 associated cytokines IL-12, IFN-?
Positive_regulation (cytokines) of Localization (release) of Th1 associated with cytokine
4) Confidence 0.16 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0.33 Pain Relevance 0.30
CD has been traditionally described as a Th1 mediated disease with the predominant cytokines being the pro-inflammatory cytokines IFN?
Positive_regulation (mediated) of Localization (disease) of Th1 associated with inflammation, disease and cytokine
5) Confidence 0.14 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721383 Disease Relevance 1.62 Pain Relevance 0.38
Thus, we and others have proposed adverse effects of altered immunity (upregulated innate mononuclear cell immunity/Th1 cytokine secretion and downregulated adaptive immunity) in AD patients, and this has led us and others to focus on three diverse treatment modalities in AD transgenic mice models which seem to "re-balance" pro- versus anti-inflammatory responses in the AD brain.
Positive_regulation (upregulated) of Localization (secretion) of Th1 in brain associated with targeted disruption, inflammatory response, disease and cytokine
6) Confidence 0.13 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 1.43 Pain Relevance 0.37
This would shed further light on the detrimental (increased expression of CXCR3-ligating chemokines, Th1 recruitment and associated pathology) versus beneficial (optimal Th1 responses required for macrophage activation and mycobacterial control) effects of early neutrophil influx in TB pathogenesis.
Positive_regulation (increased) of Localization (recruitment) of Th1 in macrophage associated with mycobacterial infection and chemokine
7) Confidence 0.11 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.05 Pain Relevance 0.12
balance between Th1 and Th2 immune responses appears to be controlled by
Positive_regulation (balance) of Localization (responses) of Th1
8) Confidence 0.09 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.44 Pain Relevance 0.11

General Comments

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