INT228084

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.54
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm2) plasma membrane (Chrm2) signal transducer activity (Chrm2)
Anatomy Link Frequency
B cells 4
T cell 1
Chrm2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 20 84.56 Quite High
cytokine 154 63.08 Quite High
Potency 23 50.00 Quite Low
agonist 11 46.24 Quite Low
anesthesia 7 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 315 96.76 Very High Very High Very High
Targeted Disruption 63 96.04 Very High Very High Very High
Death 7 91.80 High High
Retroviridae Infections 7 76.96 Quite High
Lymphatic System Cancer 28 55.88 Quite High
Viral Infection 7 51.92 Quite High
Sprains And Strains 17 32.24 Quite Low
Epstein-barr Virus 168 27.12 Quite Low
Lymphocytic Choriomeningitis 7 21.88 Low Low
Contagious Ecthyma 21 11.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At four days post-transduction, B cells expressing M2 were CD19+, CD25high, GL7high, B220low, I-Ab low, surface IgD?
Localization (were) of M2 in B cells
1) Confidence 0.36 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.15 Pain Relevance 0
These data point to a potential role of M2 protein-mediated IL-10 secretion in the quiescence of the virus-specific T cell response in vivo which may facilitate both the efficient establishment of latency as well as reactivation from latency.


Localization (secretion) of M2 in T cell
2) Confidence 0.34 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.18 Pain Relevance 0
In addition, these studies link M2 functional domains that play a critical role in MHV68 latency in vivo to M2-driven IL-10 secretion.
Localization (secretion) of M2
3) Confidence 0.34 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.24 Pain Relevance 0
In addition, the M2-transduced B cells secreted significantly higher levels of IgG on days 4–6 post-transduction than the cells transduced with the control retrovirus (Figure 3B).
Localization (secreted) of M2 in B cells
4) Confidence 0.34 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.08 Pain Relevance 0
With respect to M2-driven B cell proliferation and IL-10 secretion, we analyzed in primary B cells three M2 mutants which, in the context of virus infection, were severely attenuated in establishment and reactivation from MHV68 latency.
Localization (secretion) of M2 in B cells associated with infection
5) Confidence 0.30 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.24 Pain Relevance 0.03
These results demonstrate that both intracellular M2 expression and IL-10 secretion are necessary for the observed proliferative expansion of the transduced B cell population, and that neither one alone is sufficient to induce this expansion.
Localization (ion) of M2 in B cell
6) Confidence 0.30 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.07 Pain Relevance 0
This could either be due to the secretion of a “toxic” factor by the M2 expressing cells or competition for a limiting factor necessary for cell survival.
Localization (secretion) of M2
7) Confidence 0.30 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.15 Pain Relevance 0
The binding affinities (pKD, negative log dissociation constant) of AF-DX 116 for the human M2 and M3 receptor subtypes are 7.27?
Localization (subtypes) of M2
8) Confidence 0.29 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0.44 Pain Relevance 0.08

General Comments

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