INT228104

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Context Info
Confidence 0.77
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 12.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Vav1)
Anatomy Link Frequency
B cells 1
Vav1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 35 34.92 Quite Low
Pain 13 20.60 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 846 100.00 Very High Very High Very High
Lymphatic System Cancer 576 100.00 Very High Very High Very High
Leukemia 273 100.00 Very High Very High Very High
Precursor Cell Lymphoblastic Leukemia-lymphoma 78 99.36 Very High Very High Very High
Hematologic Neoplasms 13 98.28 Very High Very High Very High
Chronic Myeloid Leukemia 13 97.68 Very High Very High Very High
Targeted Disruption 16 90.08 High High
Sprains And Strains 69 89.72 High High
Htlv Types I And Ii 13 86.60 High High
Chronic Lymphoid Leukemia 52 85.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next analyzed whether the expression levels of VAV1 and RASGRF2 genes were significantly altered in specific subgroups of patients affected of leukemia, lymphoma or myeloma.
Spec (whether) Gene_expression (expression) of VAV1 associated with leukemia and lymphatic system cancer
1) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.12 Pain Relevance 0
To this end, we first used a standard bioinformatics comparison tool available in that database to investigate whether the expression of VAV1 and/or RASGRF2 genes was deregulated in hematopoietic tumor cells relative to their normal cell counterparts.
Gene_expression (expression) of VAV1 associated with cancer
2) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.13 Pain Relevance 0
The interest on this possibility has been also fueled by observations indicating that Vav and Rho/Rac family members are overexpressed in certain types of human tumors [2], [30]-[35].
Gene_expression (overexpressed) of Vav associated with cancer
3) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.05 Pain Relevance 0
We next analyzed whether the expression levels of VAV1 and RASGRF2 genes were significantly altered in specific subgroups of patients affected of leukemia, lymphoma or myeloma.
Gene_expression (levels) of VAV1 associated with leukemia and lymphatic system cancer
4) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.12 Pain Relevance 0
Vav1 is expressed specifically in lymphoid lineage cells, whereas Vav2 and Vav3 are more widely expressed [5], [7].
Gene_expression (expressed) of Vav1
5) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.65 Pain Relevance 0
The settings for the searches were: gene: VAV1 or RASGRF2; cancer type: leukemia, lymphoma and myeloma; dataset size: microarray data containing a minimum of 75 independent samples; microarray platform: unrestricted; gene rank: top 10%; P value?
Gene_expression (leukemia) of VAV1 associated with leukemia, lymphatic system cancer and cancer
6) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.54 Pain Relevance 0
The settings for the searches were: gene: VAV1 or RASGRF2; cancer type: leukemia, lymphoma and myeloma; dataset size: microarray data containing a minimum of 75 independent samples; microarray platform: unrestricted; gene rank: top 10%; P value?
Gene_expression (size) of VAV1 associated with leukemia, lymphatic system cancer and cancer
7) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.54 Pain Relevance 0
The settings for the searches were: gene: VAV1 or RASGRF2; cancer type: leukemia, lymphoma and myeloma; dataset size: microarray data containing a minimum of 75 independent samples; microarray platform: unrestricted; gene rank: top 10%; P value?
Gene_expression (lymphoma) of VAV1 associated with leukemia, lymphatic system cancer and cancer
8) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.54 Pain Relevance 0
In this context, it is worth mentioning that Tybulewicz’s group has shown recently that deficiencies in either Rac or Vav family genes may favor the survival of TCR?
Gene_expression (deficiencies) of Vav
9) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.38 Pain Relevance 0
Number LYRT101, Origene Technologies) was used to analyze the expression of VAV1 and RASGRF2 transcripts in different subsets of lymphomas.
Spec (analyze) Gene_expression (expression) of VAV1 associated with lymphatic system cancer
10) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.37 Pain Relevance 0
However, our present data puts a note of caution on those possible avenues, since they indicate that the blockage of Vav family–dependent signaling could be highly counterproductive in the case of lymphoblastic lymphoma patients with reduced levels of RASGRF2 gene expression in tumor cells.
Gene_expression (counterproductive) of Vav associated with cancer and precursor cell lymphoblastic leukemia-lymphoma
11) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.05 Pain Relevance 0
The take home message of these studies is that the human VAV1 and RASGRF2 genes do not show a consistent and generalizable change pattern in hematopoietic tumors such as lymphomas, leukemias or myelomas.
Gene_expression (genes) of VAV1 associated with leukemia, lymphatic system cancer and cancer
12) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.02 Pain Relevance 0
The above observations indicated that the deletion of the Vav1 and/or Rasgrf2 gene could play a role in the development of lymphoid tumors in humans.
Gene_expression (deletion) of Vav1 associated with cancer
13) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.17 Pain Relevance 0
These results suggest that the changes in the expression profile of VAV1 and RASGRF2 genes are not a general event associated to the progression of hematopoietic tumors.
Gene_expression (expression) of VAV1 associated with cancer
14) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.24 Pain Relevance 0
M2 co-immunoprecipitates with Vav1 in S11 B cells, a MHV68 latently infected cell line, and M2 and Vav1 overexpression in A20 B cells leads to Vav1 phosphorylation, trimerization with Fyn, and downstream activation of Rac1 [27].
Gene_expression (overexpression) of Vav1 in B cells
15) Confidence 0.36 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.26 Pain Relevance 0

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