INT228105

Context Info Confidence 0.25 First Reported 2008 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 5 Total Number 6 Disease Relevance 3.17 Pain Relevance 0.75

signal transduction (Chrm2) plasma membrane (Chrm2) signal transducer activity (Chrm2)

Anatomy Link Frequency T cells 4 macrophages 2 Chrm2 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 132 97.96 agonist 16 97.32 chemokine 6 93.84 cytokine 70 93.44 Inflammatory mediators 6 74.28 Inflammatory stimuli 8 61.36 Inflammatory response 6 53.00 Kinase C 8 43.56 anesthesia 7 5.00 cINOD 2 5.00

Disease Link Frequency Relevance Heat Infection 138 99.60 Atherosclerosis 10 99.28 Cancer 164 98.72 Disease 15 98.32 INFLAMMATION 152 97.96 Cytomegalovirus Infection 21 90.52 Breast Cancer 2 81.44 Confusion 2 77.64 Metabolic Disorder 2 69.12 Immunization 21 61.52

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We next examined whether loss of M2 expression and the concomitant reduction in IL-10 expression might alter the CD8 T cell response to MHV68 since IL-10 is known to suppress T cell responses [18].

Negative_regulation (loss) of Gene_expression (expression) of M2 in T cell

1) Confidence 0.25 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.40 Pain Relevance 0

Loss of M2 expression during MHV68 infection correlates with an increase in virus-specific, activated CD8+ T cells

Negative_regulation (Loss) of Gene_expression (expression) of M2 in T cells associated with infection

2) Confidence 0.25 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.40 Pain Relevance 0

As such, we turned our attention to further investigating the impact of loss of M2 expression on virus infection in vivo.

Spec (investigating) Negative_regulation (loss) of Gene_expression (expression) of M2 associated with infection

3) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.15 Pain Relevance 0

Three separate replication-defective rAd serotype 5 vectors expressing HA (KAN-1), NP (KAN-1), and M2 (KAN-1) genes were produced as previously described [23].

Negative_regulation (defective) of Gene_expression (produced) of M2

4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.15 Pain Relevance 0

with a mixture of M1 and M2 markers and considerable differences between tumor

Negative_regulation (mixture) of Gene_expression (markers) of M2 associated with cancer

5) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 1.08 Pain Relevance 0.22

PPARs and M2 activation of macrophages

Negative_regulation (PPARs) of Gene_expression (activation) of M2 in macrophages

6) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.99 Pain Relevance 0.53

General Comments

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