INT228105

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.17
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm2) plasma membrane (Chrm2) signal transducer activity (Chrm2)
Anatomy Link Frequency
T cells 4
macrophages 2
Chrm2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 132 97.96 Very High Very High Very High
agonist 16 97.32 Very High Very High Very High
chemokine 6 93.84 High High
cytokine 70 93.44 High High
Inflammatory mediators 6 74.28 Quite High
Inflammatory stimuli 8 61.36 Quite High
Inflammatory response 6 53.00 Quite High
Kinase C 8 43.56 Quite Low
anesthesia 7 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 138 99.60 Very High Very High Very High
Atherosclerosis 10 99.28 Very High Very High Very High
Cancer 164 98.72 Very High Very High Very High
Disease 15 98.32 Very High Very High Very High
INFLAMMATION 152 97.96 Very High Very High Very High
Cytomegalovirus Infection 21 90.52 High High
Breast Cancer 2 81.44 Quite High
Confusion 2 77.64 Quite High
Metabolic Disorder 2 69.12 Quite High
Immunization 21 61.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next examined whether loss of M2 expression and the concomitant reduction in IL-10 expression might alter the CD8 T cell response to MHV68 since IL-10 is known to suppress T cell responses [18].
Negative_regulation (loss) of Gene_expression (expression) of M2 in T cell
1) Confidence 0.25 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.40 Pain Relevance 0
Loss of M2 expression during MHV68 infection correlates with an increase in virus-specific, activated CD8+ T cells
Negative_regulation (Loss) of Gene_expression (expression) of M2 in T cells associated with infection
2) Confidence 0.25 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.40 Pain Relevance 0
As such, we turned our attention to further investigating the impact of loss of M2 expression on virus infection in vivo.


Spec (investigating) Negative_regulation (loss) of Gene_expression (expression) of M2 associated with infection
3) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.15 Pain Relevance 0
Three separate replication-defective rAd serotype 5 vectors expressing HA (KAN-1), NP (KAN-1), and M2 (KAN-1) genes were produced as previously described [23].
Negative_regulation (defective) of Gene_expression (produced) of M2
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.15 Pain Relevance 0
with a mixture of M1 and M2 markers and considerable differences between tumor
Negative_regulation (mixture) of Gene_expression (markers) of M2 associated with cancer
5) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 1.08 Pain Relevance 0.22
PPARs and M2 activation of macrophages
Negative_regulation (PPARs) of Gene_expression (activation) of M2 in macrophages
6) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.99 Pain Relevance 0.53

General Comments

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