INT228110

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.66
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) signal transduction (Chrm2) extracellular region (Il10)
intracellular (Il10) plasma membrane (Chrm2) signal transducer activity (Chrm2)
Anatomy Link Frequency
B cells 6
dendritic cells 2
Chrm2 (Mus musculus)
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 88 70.48 Quite High
chemokine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 180 92.08 High High
Splenomegaly 4 89.84 High High
Epstein-barr Virus 96 61.64 Quite High
Cytomegalovirus Infection 40 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 16 5.00 Very Low Very Low Very Low
Sarcoma 12 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Contagious Ecthyma 12 5.00 Very Low Very Low Very Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Salivary Gland Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, these investigators showed that M2 is transcribed by infected dendritic cells, although they did not demonstrate that IL-10 secretion was mediated by M2 [36].
M2 Positive_regulation (mediated) of Localization (secretion) of IL-10 in dendritic cells
1) Confidence 0.33 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.14 Pain Relevance 0.03
The latter result provides further evidence that M2 is able to increase IL-10 secretion by B cells – independent of LPS stimulation.


M2 Positive_regulation (increase) of Localization (secretion) of IL-10 in B cells
2) Confidence 0.22 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.09 Pain Relevance 0.07
In primary murine B cells, M2-driven proliferation was dependent on the B cell's ability to secrete IL-10 and respond to IL-10 signaling.
M2 Positive_regulation (dependent) of Localization (secrete) of IL-10 in B cell
3) Confidence 0.22 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.18 Pain Relevance 0
These results provide strong evidence that M2 induction of IL-10 secretion, either from latently infected B cells or some other latency reservoir (e.g., infected macrophages or dendritic cells), contributes significantly to the serum levels of IL-10 observed during MHV68 infection following either intranasal or intraperitoneal virus inoculation.


M2 Positive_regulation (induction) of Localization (secretion) of IL-10 in B cells associated with infection
4) Confidence 0.22 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.25 Pain Relevance 0.03

General Comments

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