INT228121

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.01
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Bcl2l11) mitochondrion (Bcl2l11) cytoplasm (Bcl2l11)
Anatomy Link Frequency
T cell 1
Bcl2l11 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 63 96.56 Very High Very High Very High
cytokine 12 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 105 98.76 Very High Very High Very High
Colon Cancer 75 98.64 Very High Very High Very High
Herpes Simplex Virus 18 96.00 Very High Very High Very High
Apoptosis 175 95.24 Very High Very High Very High
Metastasis 75 94.64 High High
Death 53 93.56 High High
Infection 24 89.68 High High
Breast Cancer 12 89.56 High High
Carcinoma 75 79.44 Quite High
Cold Sores 18 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore examined the individual and combined roles of Bim and Fas in the T cell immune response to mouse ?
Spec (examined) Regulation (roles) of Bim in T cell
1) Confidence 0.45 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 1.25 Pain Relevance 0
Interestingly, decreased FAK activation and protein levels preceded the alterations in Mcl-1 and Bim levels (Figure 4D).
Regulation (alterations) of Bim
2) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.36 Pain Relevance 0.05
Moreover, our analyses indicate focal adhesion protein loss of activity and degradation temporally precedes alterations in Mcl-1 and Bim expression levels, which themselves regulate activation of the caspase family members (Figure 9).
Regulation (alterations) of Bim associated with adhesions
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.30 Pain Relevance 0
Data herein delineate the molecular process by which CXCL12 re-expression regulates Bim and Mcl-1 to initiate anoikis in colorectal cancers.
Regulation (regulates) of Bim associated with colon cancer
4) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.10 Pain Relevance 0.14

General Comments

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