INT228135

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fasl) extracellular space (Fasl) extracellular region (Fasl)
cytoplasmic membrane-bounded vesicle (Fasl) plasma membrane (Fasl) lysosome (Fasl)
Anatomy Link Frequency
T cells 2
Trav6-3 (Mus musculus)
Fasl (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 3 15.04 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 18 97.24 Very High Very High Very High
Infection 24 96.88 Very High Very High Very High
Death 32 96.56 Very High Very High Very High
Apoptosis 37 79.92 Quite High
Herpes Simplex Virus 18 57.84 Quite High
Lymphadenopathy 13 5.00 Very Low Very Low Very Low
Autoimmune Disease 7 5.00 Very Low Very Low Very Low
Splenomegaly 5 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that Fas activation, which requires repeated TCR stimulation to upregulate FasL in T cells, is not involved in the shutdown of acute immune responses; instead, this death is mediated predominantly by Bim.


Positive_regulation (requires) of TCR Positive_regulation (upregulate) of FasL in T cells associated with death
1) Confidence 0.14 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 1.39 Pain Relevance 0

General Comments

This test has worked.

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