INT22815

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Context Info
Confidence 0.49
First Reported 1990
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 14.58
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1) DNA binding (RB1) nucleus (RB1)
molecular_function (RB1) cell division (RB1) cellular_component (RB1)
Anatomy Link Frequency
myometrium 1
cornea 1
stomach 1
endometrium 1
telomere 1
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 13 94.60 High High
abdominal pain 3 91.08 High High
lidocaine 1 89.08 High High
Inflammation 83 88.72 High High
withdrawal 27 85.12 High High
narcan 9 84.92 Quite High
antagonist 8 79.92 Quite High
Opioid 13 79.48 Quite High
Inflammatory stimuli 6 78.12 Quite High
cINOD 3 77.04 Quite High
Disease Link Frequency Relevance Heat
Cancer 229 100.00 Very High Very High Very High
Retinoblastoma 217 100.00 Very High Very High Very High
Pressure And Volume Under Development 6 99.98 Very High Very High Very High
Leiomyosarcoma 24 99.68 Very High Very High Very High
Genital Human Papilloma Virus 111 99.14 Very High Very High Very High
Asymptomatic Infections 54 98.46 Very High Very High Very High
Breast Cancer 9 97.24 Very High Very High Very High
Apoptosis 329 97.04 Very High Very High Very High
Aging 15 96.90 Very High Very High Very High
Keratoconjunctivitis 1 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In non hereditary cases (45% of all patients) both RB1 alleles are inactivated somatically in a single developing retinal progenitor cell.
Positive_regulation (inactivated) of RB1
1) Confidence 0.49 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1586012 Disease Relevance 1.39 Pain Relevance 0
In hereditary cases (representing approximately 55% of the cases) patients carry a germline inactivated RB1 allele present in all cells in the body and somatic loss of the second allele in retinal cells.
Positive_regulation (inactivated) of RB1 in body
2) Confidence 0.49 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1586012 Disease Relevance 1.43 Pain Relevance 0
B activation led to an increase in PRA and PRB mRNA and protein expression.
Positive_regulation (increase) of PRB
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.15 Pain Relevance 0
Intramucosal leiomyosarcoma of the stomach following hereditary retinoblastoma in childhood – a case report and review of the literature

Background

Positive_regulation (following) of retinoblastoma in stomach associated with leiomyosarcoma and retinoblastoma
4) Confidence 0.44 Published 2008 Journal World J Surg Oncol Section Title Doc Link PMC2615012 Disease Relevance 1.34 Pain Relevance 0.09
Since it is unethical to conduct a prospective experiment without antibiotic treatment of pregnant women with subclinical infection, we developed a computer simulation of the molecular events that lead to an increase in the PRA/PRB ratio to labor levels in the myometrium, and tested the effect of progesterone supplementation and Cox2 specific inhibitors on labor associated changes in biochemical markers as the end-point.


Positive_regulation (increase) of PRA/PRB in myometrium associated with asymptomatic infections
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.83 Pain Relevance 0.08
Therefore, the data suggest that under the effect of OGF, p21 protein levels were upregulated, and activated the p21-Rb pathway that, in turn, mediated the cell cycle blockade.
Positive_regulation (activated) of Rb associated with retinoblastoma
6) Confidence 0.40 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.26 Pain Relevance 0.32
B activation the increase in PRA/PRB ratio was highest (2.9 fold higher than the lowest-nonlabor level of NF-?
Positive_regulation (increase) of PRA/PRB
7) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.27 Pain Relevance 0
B activation leads to an increase in PRA/PRB ratio.
Positive_regulation (increase) of PRA/PRB
8) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.43 Pain Relevance 0.24
In LASIK-induced neurotrophic epitheliopathy RB staining typically affects the cornea (Wilson and Ambrosio 2001; Savini et al 2004).
Positive_regulation (induced) of RB in cornea
9) Confidence 0.28 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698717 Disease Relevance 0.98 Pain Relevance 0
Cell swelling induced a third conductance with a low permeability to Rb (PK/PRb approximately equal to 10) that was quinidine sensitive.
Positive_regulation (induced) of PRb associated with pressure and volume under development
10) Confidence 0.21 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2333950 Disease Relevance 0.26 Pain Relevance 0.14
That both LTPOCs produce a hyperprogestational endometrial milieu is suggested by the observation of significantly high endometrial levels of the progesterone receptor (PR) isoforms PRA and PRB after administration of Norplant [24] as well as the injectable LTPOC, Provera [23], whereas PRA appears to mediate the long-term effects of LNG in the endometrium during intrauterine LNG contraception [6].
Positive_regulation (levels) of PRB in endometrium
11) Confidence 0.20 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1403781 Disease Relevance 0.05 Pain Relevance 0.07
B activation PRA and PRB mRNA and protein curves shifted to the left and the PRA/PRB ratio increased to labor levels (6.2±1.5) [9] earlier (Figure 3).
Positive_regulation (activation) of PRB
12) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.25 Pain Relevance 0
B activation on myometrial PRA, PRB or ER alpha expression.
Positive_regulation (activation) of PRB
13) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.52 Pain Relevance 0.13
Sulindac sulfide induced expression of p21wafl/cipl in a dose-dependent fashion, decreased cyclin D1 protein levels, and increased Rb hypophosphorylation. p21waf1/cip1 protein levels increased without a significant increase in wild-type p53, suggesting that sulindac sulfide induces a p53-independent pathway regulating p2lwafl/ciP1 protein levels in SCCHN.
Positive_regulation (increased) of Rb
14) Confidence 0.17 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 17172818 Disease Relevance 0.36 Pain Relevance 0.08
increasing the amount of hypophosphorylated pRb able to bind E2F.
Positive_regulation (increasing) of pRb
15) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.53 Pain Relevance 0.04
This interaction could also protect pRb from degradation, which would allow cell cycle arrest without leading to apoptosis.
Positive_regulation (protect) of pRb associated with apoptosis
16) Confidence 0.08 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.78 Pain Relevance 0
The RBBP4, RBBP5/RBQ-3, RBBP6, and JARID1A or RBBP2 genes were all induced in WTSTS cells and are important for pRb function [68-71].
Positive_regulation (important) of pRb
17) Confidence 0.08 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.54 Pain Relevance 0
Functional inactivation of Rb by E7 protein also leads to p16INK4A overexpression.
Positive_regulation (inactivation) of Rb
18) Confidence 0.07 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3003991 Disease Relevance 1.27 Pain Relevance 0
The mechanisms used by high-risk HPV genotypes (HPV 16, 18, 31, 33, 39, 45, 52, 58 and 67) to overcome the normal cell cycle control is mediated by the HPV viral oncoproteins E6 and E7, which cause inactivation of the tumor suppressor genes p53 and Rb [11].
Positive_regulation (inactivation) of Rb associated with genital human papilloma virus and cancer
19) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1475606 Disease Relevance 2.32 Pain Relevance 0
Cellular senescence is associated with many molecular mechanisms, including telomere erosion and oxidative damage caused by O2, H2O2 and tert-butyl-hydroperoxide, leading to activation of p53, retinoblastoma gene and insulin-like growth factor (IGF)/Akt pathways [106-109].
Positive_regulation (activation) of retinoblastoma gene in telomere associated with aging and retinoblastoma
20) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 0.61 Pain Relevance 0.07

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