INT228188

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 6.96
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr2) plasma membrane (Tlr2) intracellular (Tlr2)
cytoplasm (Tlr2)
Anatomy Link Frequency
kidney 2
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 42 99.52 Very High Very High Very High
Inflammation 103 99.32 Very High Very High Very High
Inflammatory mediators 4 94.04 High High
fibrosis 102 87.84 High High
rheumatoid arthritis 4 74.28 Quite High
metalloproteinase 47 61.92 Quite High
Bile 6 31.04 Quite Low
Inflammatory response 23 5.00 Very Low Very Low Very Low
chemokine 22 5.00 Very Low Very Low Very Low
Angina 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hydronephrosis 231 100.00 Very High Very High Very High
Ureteral Obstruction 108 99.84 Very High Very High Very High
Cancer 208 99.72 Very High Very High Very High
Stress 24 99.44 Very High Very High Very High
INFLAMMATION 129 99.32 Very High Very High Very High
Injury 159 99.04 Very High Very High Very High
Glioblastoma 30 96.52 Very High Very High Very High
Infection 13 96.48 Very High Very High Very High
Hemophilus Infection 89 96.04 Very High Very High Very High
Thrombosis 10 90.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No effect of TLR2 deficiency on UUO-induced tubular injury and ECM accumulation
Neg (No) Regulation (effect) of Gene_expression (deficiency) of TLR2 associated with ureteral obstruction and injury
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.78 Pain Relevance 0.04
The fold changes in TLR2 and TLR4 levels with HSP70 stimulation were higher in patients with AMI (both local and systemic samples) compared with patients with SA and controls (Figure 4).
Regulation (changes) of Gene_expression (levels) of TLR2
2) Confidence 0.38 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.08 Pain Relevance 0
Activation of p38 MAPK up-regulates inflammatory cytokines, mucin MUC5AC and down-regulates TLR2 expression while activation of NF-kappa B increases the expression of IL-8, IL-1?
Regulation (regulates) of Gene_expression (expression) of TLR2 associated with inflammation and cytokine
3) Confidence 0.29 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.04 Pain Relevance 0.15
This might indicate that the antibody we used is not sensitive enough to detect very low levels of protein or that some sort of regulation of the TLR2 expression is being applied at the post-transcriptional, translational or proteosomal level.
Regulation (regulation) of Gene_expression (expression) of TLR2 associated with hydronephrosis
4) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.80 Pain Relevance 0.18
To evaluate the influence of fibrinogenesis at different stages on the expression and localization of TLR2 we next measured the amount of mRNA and protein in UUO-injured kidney of TLR2+/+ mice at several time points.
Regulation (influence) of Gene_expression (expression) of TLR2 in kidney associated with ureteral obstruction
5) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.04 Pain Relevance 0.07
DC activation in response to GL26 tumor extracts was dependent on TLR2 expression; we observed that the release of the pro-inflammatory cytokines TNF?
Regulation (dependent) of Gene_expression (expression) of TLR2 associated with inflammation, cancer and cytokine
6) Confidence 0.27 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.12 Pain Relevance 0.28
Changes in TLR2 and TLR4 levels in response to HSP70
Regulation (Changes) of Gene_expression (levels) of TLR2
7) Confidence 0.23 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.09 Pain Relevance 0

General Comments

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