INT228192

Context Info Confidence 0.35 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.96 Pain Relevance 0.03

cytosol (Map2k2) kinase activity (Map2k2)

Anatomy Link Frequency HT-29 1 Map2k2 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 2 63.52 Inflammation 8 39.08 Inflammatory mediators 2 34.48 metalloproteinase 7 5.00 COX-2 inhibitor 2 5.00 Inflammatory response 2 5.00 Perioperative pain 1 5.00 anesthesia 1 5.00 rheumatoid arthritis 1 5.00 isoflurane 1 5.00

Disease Link Frequency Relevance Heat Colon Cancer 45 90.72 Hemophilus Infection 89 84.88 Targeted Disruption 14 75.60 Adenocarcinoma 8 67.76 Skin Cancer 2 50.60 INFLAMMATION 12 39.08 Infection 19 36.92 Cancer 37 5.00 Sprains And Strains 11 5.00 Metastasis 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, the single inactivation of MEK2 was still capable of abolishing the proliferation of HT-29 cells even in the presence of high MEK1 levels.

Negative_regulation (inactivation) of MEK2 in HT-29

1) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.50 Pain Relevance 0

Mancuso et al. reported that neither p38 nor ERK MAPK blockade had any effect on Group B streptococci (GBS)-induced NF-kappa B binding activity [21].

Neg (neither) Negative_regulation (blockade) of ERK MAPK

2) Confidence 0.02 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 0.46 Pain Relevance 0.03

General Comments

This test has worked.