INT228195

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 12.17
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr2) plasma membrane (Tlr2) intracellular (Tlr2)
cytoplasm (Tlr2)
Anatomy Link Frequency
macrophages 3
Neutrophils 3
B16-F1 2
monocytes 2
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 242 100.00 Very High Very High Very High
agonist 12 100.00 Very High Very High Very High
Inflammation 274 99.42 Very High Very High Very High
Inflammatory mediators 5 94.24 High High
tolerance 23 93.16 High High
Inflammatory response 63 81.76 Quite High
Arthritis 8 77.52 Quite High
metalloproteinase 4 71.28 Quite High
chemokine 14 64.36 Quite High
ischemia 4 56.00 Quite High
Disease Link Frequency Relevance Heat
Mycobacterial Infection 216 100.00 Very High Very High Very High
Sepsis 44 99.84 Very High Very High Very High
INFLAMMATION 347 99.42 Very High Very High Very High
Infection 395 99.26 Very High Very High Very High
Apoptosis 66 98.64 Very High Very High Very High
Latent Tuberculosis 18 97.38 Very High Very High Very High
Disease 108 96.56 Very High Very High Very High
Hemophilus Infection 89 96.24 Very High Very High Very High
Bacteremia 39 93.00 High High
Cancer 90 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Firstly, the highly metastatic B16 cells not only release higher level of HSP60, but also have a higher-level expression of TLR2 and basal activity of Stat3 compared to low metastatic B16-F1 cells.
Negative_regulation (have) of Gene_expression (expression) of TLR2 in B16-F1
1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.75 Pain Relevance 0.05
This suggests that circulating monocytes may be a major cellular source of TLR2 expression in patients with AMI.
Negative_regulation (source) of Gene_expression (expression) of TLR2 in monocytes
2) Confidence 0.36 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.50 Pain Relevance 0.16
Activation of p38 MAPK up-regulates inflammatory cytokines, mucin MUC5AC and down-regulates TLR2 expression while activation of NF-kappa B increases the expression of IL-8, IL-1?
Negative_regulation (down) of Gene_expression (expression) of TLR2 associated with inflammation and cytokine
3) Confidence 0.28 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.04 Pain Relevance 0.15
To better appreciate the individual and combined contribution of CD14 and TLR2 signaling to the M?
Negative_regulation (appreciate) of Gene_expression (contribution) of TLR2
4) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.08 Pain Relevance 0.10
Biglycan null mice have a considerable survival benefit in LPS-induced sepsis due to reduced TLR2 and 4 dependent cytokine synthesis, cellular infiltration into tissues [23], and lower levels of active caspase-1 and mature IL-1?
Negative_regulation (reduced) of Gene_expression (synthesis) of TLR2 associated with sepsis and cytokine
5) Confidence 0.25 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.23 Pain Relevance 0.39
Biglycan null mice have a considerable survival benefit in LPS-induced sepsis due to reduced TLR2 and 4 dependent cytokine synthesis, cellular infiltration into tissues [23], and lower levels of active caspase-1 and mature IL-1?
Negative_regulation (reduced) of Gene_expression (synthesis) of TLR2 associated with sepsis and cytokine
6) Confidence 0.25 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.23 Pain Relevance 0.39
In contrast, intrauterine delivery of TLR2 agonists did not induce increased TNF-?
Negative_regulation (delivery) of Gene_expression (agonists) of TLR2 associated with agonist
7) Confidence 0.24 Published 2010 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2933901 Disease Relevance 1.20 Pain Relevance 0.08
IL-10 administration suppressed the formation of PGE-2 by neutrophils and macrophages, in which case the expression of TLR2 in these cells suppressed and induced the expression of CR3.
Negative_regulation (suppressed) of Gene_expression (expression) of TLR2 in macrophages
8) Confidence 0.17 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.61 Pain Relevance 0.03
Neutrophils from CR3-siRNA–transfected and –infected animals revealed greater expression of TLR2 and Fc?
Negative_regulation (revealed) of Gene_expression (expression) of TLR2 in Neutrophils
9) Confidence 0.17 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.17 Pain Relevance 0.05
While the baseline decrease in expression of TLR2 and 9 mRNA has been shown by us previously, the impact on antigen-driven TLR expression is striking.
Negative_regulation (decrease) of Gene_expression (expression) of TLR2
10) Confidence 0.15 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 1.33 Pain Relevance 0.04
By analyzing the baseline and mycobacterial antigen–stimulated expression of TLR1, 2, 4, and 9 (in individuals with latent tuberculosis [TB] with or without filarial infection), we were able to demonstrate that filarial infection, coincident with Mtb, significantly diminishes both baseline and Mtb antigen-specific TLR2 and TLR9 expression.
Negative_regulation (diminishes) of Gene_expression (expression) of TLR2 associated with mycobacterial infection, latent tuberculosis and infection
11) Confidence 0.15 Published 2009 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2710006 Disease Relevance 1.65 Pain Relevance 0.18
Dually infected individuals exhibit a significant decrease in the baseline as well as Mtb antigen-induced expression of TLR2 and 9.
Negative_regulation (decrease) of Gene_expression (expression) of TLR2 associated with mycobacterial infection
12) Confidence 0.13 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 1.37 Pain Relevance 0.03
Transcriptional inhibition that is potentially mediated by a CK2-mediated phosphorylation of Sp1 has also been suggested for the flow-dependent suppression of endothelial Toll-like receptor 2 expression [34].
Negative_regulation (suppression) of Gene_expression (expression) of endothelial Toll-like receptor 2
13) Confidence 0.06 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.40 Pain Relevance 0.05
IL-10 administration suppressed the formation of PGE-2 by neutrophils and macrophages, in which case the expression of TLR2 in these cells suppressed and induced the expression of CR3.
Negative_regulation (suppressed) of in neutrophils Gene_expression (expression) of TLR2 in macrophages
14) Confidence 0.06 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.61 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox