INT228215

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.47
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr2, Tlr4) plasma membrane (Tlr2, Tlr4) intracellular (Tlr2, Tlr4)
cytoplasm (Tlr2, Tlr4)
Tlr2 (Mus musculus)
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 2 40.04 Quite Low
Inflammation 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemophilus Infection 89 99.70 Very High Very High Very High
Targeted Disruption 10 97.16 Very High Very High Very High
Sprains And Strains 11 83.88 Quite High
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Infection 12 5.00 Very Low Very Low Very Low
Pulmonary Disease 3 5.00 Very Low Very Low Very Low
Pneumonia 2 5.00 Very Low Very Low Very Low
Skin Cancer 1 5.00 Very Low Very Low Very Low
Bacterial Meningitis 1 5.00 Very Low Very Low Very Low
Bacterial Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these data indicate that NTHi-induced COX-2 expression is mediated by TLR2-dependent pathway, but independently from TLR4.


TLR2 Positive_regulation (mediated) of Gene_expression (expression) of TLR4 associated with hemophilus infection
1) Confidence 0.19 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.47 Pain Relevance 0

General Comments

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