INT228216

Context Info Confidence 0.09 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.11 Pain Relevance 0.15

cytoplasm (Mapk14, Tlr2) mitochondrion (Mapk14) cell morphogenesis (Mapk14) intracellular (Tlr2) response to stress (Mapk14) cytosol (Mapk14)

Mapk14 (Mus musculus) Tlr2 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 8 100.00 cytokine 2 100.00 Inflammatory mediators 2 97.32 COX-2 inhibitor 2 5.00 Inflammatory response 2 5.00 anesthesia 1 5.00 rheumatoid arthritis 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 12 100.00 Infection 12 99.76 Hemophilus Infection 89 99.32 Skin Cancer 1 82.88 Targeted Disruption 10 75.60 Respiratory Syncytial Virus 1 23.60 Chlamydia Infection 1 20.92 Bacterial Meningitis 1 20.48 Sprains And Strains 11 5.00 Pulmonary Disease 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Activation of p38 MAPK up-regulates inflammatory cytokines, mucin MUC5AC and down-regulates TLR2 expression while activation of NF-kappa B increases the expression of IL-8, IL-1?

Positive_regulation (Activation) of p38 Regulation (regulates) of Gene_expression (expression) of TLR2 associated with inflammation and cytokine

1) Confidence 0.09 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.11 Pain Relevance 0.15

General Comments

This test has worked.