INT22823

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Context Info
Confidence 0.45
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.89
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)
Anatomy Link Frequency
neutrophil 6
blood 2
plasma 2
immune cells 2
nasal 2
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 10 99.98 Very High Very High Very High
aspirin 16 99.08 Very High Very High Very High
cytokine 22 97.76 Very High Very High Very High
Morphine 206 96.40 Very High Very High Very High
Inflammation 174 89.96 High High
rheumatoid arthritis 50 89.72 High High
Inflammatory response 8 89.08 High High
opioid receptor 42 87.36 High High
diclofenac 1 86.44 High High
Restless leg syndrome 5 85.04 High High
Disease Link Frequency Relevance Heat
Sepsis 48 99.70 Very High Very High Very High
Asthma 99 99.00 Very High Very High Very High
Rhinitis 18 98.40 Very High Very High Very High
Infection 27 98.24 Very High Very High Very High
Apoptosis 15 97.92 Very High Very High Very High
Pressure And Volume Under Development 2 97.32 Very High Very High Very High
Occupational Lung Diseases 3 97.04 Very High Very High Very High
Increased Venous Pressure Under Development 10 92.72 High High
Stress 7 92.40 High High
Agranulocytosis 17 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition or activation of PMN-elastase by the test substances was dependent on the type and concentration of buffer, the pH, the presence of a tenside and most notably, the presence of electrolytes.
Positive_regulation (dependent) of Positive_regulation (activation) of PMN-elastase
1) Confidence 0.45 Published 1990 Journal Arzneimittelforschung Section Abstract Doc Link 2334461 Disease Relevance 0 Pain Relevance 0.12
Heterozygous mutations in ELA2 act in a dominant manner, interfering with sub-cellular trafficking of neutrophil elastase, and leading to an accumulation of neutrophil elastase in the cytosol [10].
Positive_regulation (leading) of Positive_regulation (accumulation) of elastase in neutrophil
2) Confidence 0.40 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 1.00 Pain Relevance 0
In animal models, increased elastase activity induces a disturbance of blood coagulation, leading to hypocoagulability [5].
Positive_regulation (induces) of Positive_regulation (induces) of elastase in blood
3) Confidence 0.30 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.68 Pain Relevance 0.28
In conclusion, CPB results in statistically significant increases in endotoxin, C3a, C5a, and GE during CPB.
Positive_regulation (results) of Positive_regulation (increases) of GE
4) Confidence 0.23 Published 1994 Journal Ann. Thorac. Surg. Section Abstract Doc Link 8311599 Disease Relevance 0.37 Pain Relevance 0.07
In neutrophilic asthma, there is evidence of neutrophil activation with increased neutrophil elastase and IL-8 in induced sputum [54].
Positive_regulation (increased) of Positive_regulation (increased) of neutrophil elastase in neutrophil associated with asthma
5) Confidence 0.16 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873624 Disease Relevance 1.45 Pain Relevance 0.25
RESULTS: Indomethacin caused a concentration- and time-dependent upregulation of CD11b and CD18 expression and PMN adhesion to endothelial cells.
Positive_regulation (caused) of Positive_regulation (upregulation) of PMN in PMN
6) Confidence 0.04 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
Capsaicin induced a slight, although not significant, increase in the concentration of elastase in nasal lavage fluid in patients with allergic rhinitis (p = 0.07), but not in healthy subjects.
Neg (not) Positive_regulation (induced) of Neg (not) Positive_regulation (increase) of elastase in nasal associated with rhinitis and qutenza
7) Confidence 0.04 Published 1995 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 7697245 Disease Relevance 0.49 Pain Relevance 0.69
Both activators, as well as the preparatory procedure itself, caused PMN accumulations in the alveolar septa, septal thickening, and modest perivascular edema with intact tissue architecture.
Positive_regulation (caused) of Positive_regulation (accumulations) of PMN in thickening associated with pressure and volume under development
8) Confidence 0.02 Published 1988 Journal Int J Microcirc Clin Exp Section Abstract Doc Link 3170083 Disease Relevance 0.29 Pain Relevance 0
Similarly, exercise induced an increase of plasma elastase and of sVCAM-1 which were not affected by aspirin while they were suppressed by NCX 4016.
Positive_regulation (induced) of Positive_regulation (increase) of plasma elastase in plasma associated with aspirin
9) Confidence 0.02 Published 2007 Journal Thromb. Haemost. Section Abstract Doc Link 17334512 Disease Relevance 0.66 Pain Relevance 0.78
Increasing IL-10R1 by stimulation with lipopolysaccharide coincided with an increased responsiveness of PMN to IL-10.
Positive_regulation (increased) of Positive_regulation (responsiveness) of PMN
10) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.22 Pain Relevance 0.11
During gram-negative sepsis bacterial LPS leads to the activation of PMN and triggers the synthesis and secretion of proteases, cytokines (e.g., IL-6 and IL-8), and toxic radicals from immune cells [43], [44].
Positive_regulation (leads) of Positive_regulation (activation) of PMN in immune cells associated with sepsis and cytokine
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0.51 Pain Relevance 0.81
However, increased elastase activity due to acidic proteinase(s) is detected in BAL samples after transfection of alveolar epithelial cells with caspase-3 (Aoshiba et al 2003).
Positive_regulation (increased) of Positive_regulation (due) of elastase in epithelial cells
12) Confidence 0.01 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 1.23 Pain Relevance 0.25

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