INT228243

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 15
Disease Relevance 4.78
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Met) plasma membrane (Met) kinase activity (Met)
cytoplasm (Met)
Anatomy Link Frequency
hepatocytes 6
livers 3
blood 1
Met (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 36 83.92 Quite High
isoflurane 33 83.04 Quite High
cytokine 22 64.16 Quite High
agonist 3 51.48 Quite High
imagery 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 141 99.88 Very High Very High Very High
Necrosis 22 99.66 Very High Very High Very High
Death 11 99.16 Very High Very High Very High
Congenital Anomalies 11 97.52 Very High Very High Very High
Apoptosis 14 95.28 Very High Very High Very High
Adenocarcinoma 60 93.92 High High
Injury 11 92.92 High High
Cancer 47 90.32 High High
Gallbladder Disease 11 84.96 Quite High
Targeted Disruption 138 83.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although liver mass was slightly reduced, there were no differences in blood parameters or ploidy as estimated at 2 months of age, indicating that c-Met deficiency did not affect the postnatal liver growth (Figure S1D and E).


Negative_regulation (deficiency) of c-Met in blood
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.22 Pain Relevance 0.16
Histological examination of the regenerative livers also revealed neither increased cell death nor presence of necrosis suggesting that loss of c-Met function did not interfere with hepatocyte survival after PH.
Negative_regulation (loss) of c-Met in livers associated with necrosis and death
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.50 Pain Relevance 0.20
Both approaches caused inactivation of c-met in diverse liver cell types, and therefore the extent to which the lack of c-Met signaling specifically in hepatocytes contributed to impaired cell cycle regulation could not be elucidated.
Negative_regulation (inactivation) of c-met in hepatocytes
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.23 Pain Relevance 0
A persistent EGF supplementation in vitro was able only partially rescue the effect of Erk1/2 downregulation in c-Met depleted hepatocytes and restore to some extent the levels of cdc2, Aurora A and B, and Mad2.
Negative_regulation (downregulation) of c-Met in hepatocytes
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.08 Pain Relevance 0
We used functional test to verify the efficient inactivation of the c-met gene after Mx1-cre-induced recombination.
Negative_regulation (inactivation) of c-met
5) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.06 Pain Relevance 0.04
Furthermore, loss of c-Met in hepatocytes diminished the subsequent G1/S progression and delayed liver recovery after partial hepatectomy.
Negative_regulation (loss) of c-Met in hepatocytes
6) Confidence 0.41 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2940888 Disease Relevance 0.16 Pain Relevance 0
Mice with a selective disruption of c-met in hepatocytes appeared normal without apparent histological abnormalities.
Negative_regulation (disruption) of c-met in hepatocytes associated with congenital anomalies
7) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.24 Pain Relevance 0.05
In agreement with cell kinetics data (Figure 1A), the early priming events appeared to be unaffected by the loss of c-Met signaling in hepatocytes consistent with the previous work demonstrating that the massive changes in gene expression in the first four hours after 2/3 PH, while preparing the quiescent hepatocytes to enter cell cycle, cannot predict whether DNA replication may actually occur [15].
Negative_regulation (loss) of c-Met in hepatocytes
8) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0
Accordingly, hepatic overexpression of HGF remarkably accelerated whereas loss of c-Met signaling decreased regenerative potential of liver [7]–[10].
Negative_regulation (loss) of c-Met in liver
9) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.27 Pain Relevance 0.03
These data suggest that c-Met deficient hepatocytes were blocked in early/mid G2 phase due to failure of mitosis-specific phosphorylation events responsible for chromosome compaction.


Negative_regulation (blocked) of c-Met in hepatocytes
10) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0
A quantitative time course of BrdU incorporation showed that kinetics of DNA synthesis was conserved within the first 36 hr after PH but the peak level was significantly reduced in c-Met mutant livers (Figure 1A).
Negative_regulation (reduced) of c-Met mutant in livers
11) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.32 Pain Relevance 0
As in single infections, the c-Met kinase inhibitor reduced WT invasion to the level of ?
Negative_regulation (inhibitor) of c-Met associated with infection
12) Confidence 0.11 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.60 Pain Relevance 0
inlB invasion, or alternately whether c-Met inhibition would selectively affect WT invasion.
Spec (whether) Negative_regulation (inhibition) of c-Met
13) Confidence 0.11 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.60 Pain Relevance 0
To further address whether c-Met activation is restricted to the immediate surrounding of individual bacteria, we tested whether the c-Met kinase inhibitor used in a mixed infection would reduce both WT and ?
Spec (whether) Negative_regulation (inhibitor) of c-Met associated with infection
14) Confidence 0.11 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.61 Pain Relevance 0.03
Additionally, the molecular deregulation of the tyrosine kinase receptor c-MET has been associated with enhanced transcript levels [7].
Negative_regulation (deregulation) of c-MET
15) Confidence 0.04 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.90 Pain Relevance 0

General Comments

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