INT228246

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 8.11
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) signal transduction (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
nucleus 4
adult intestine 2
lymphocytes 2
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 28 86.72 High High
cytokine 129 86.24 High High
Inflammation 182 81.12 Quite High
agonist 12 75.08 Quite High
antagonist 12 66.88 Quite High
tolerance 37 5.00 Very Low Very Low Very Low
Inflammatory response 28 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 63 99.96 Very High Very High Very High
Cancer 1007 98.64 Very High Very High Very High
Lymphatic System Cancer 55 98.64 Very High Very High Very High
Disease 57 98.08 Very High Very High Very High
Colitis 36 97.64 Very High Very High Very High
Syndrome 40 96.48 Very High Very High Very High
Wound Healing 8 94.04 High High
Adenocarcinoma 68 91.28 High High
Obesity 342 89.80 High High
Aging 252 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Meanwhile, systemic reduction of Stat3 expression in gp130Y757F;Stat3+/- mice not only prevented gastric tumour formation [31], but also reduced their susceptibility to colonic tumourigenesis in the CAC model [93].
Negative_regulation (reduction) of Gene_expression (expression) of Stat3 associated with cancer
1) Confidence 0.58 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.91 Pain Relevance 0.07
Meanwhile, systemic reduction of Stat3 expression in gp130Y757F;Stat3+/- mice not only prevented gastric tumour formation [31], but also reduced their susceptibility to colonic tumourigenesis in the CAC model [93].
Negative_regulation (reduction) of Gene_expression (/) of Stat3 associated with cancer
2) Confidence 0.42 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.91 Pain Relevance 0.07
While epithelial Stat3 activity is dispensable during normal development and tissue homeostasis of the adult intestine, reduction of Stat3 expression, by either ablating il6 [84] or depleting the capacity of gp130 to activate Stat3, increases susceptibility to acute colitis and impairs intestinal wound healing [30].
Negative_regulation (reduction) of Gene_expression (expression) of Stat3 in adult intestine associated with colitis and wound healing
3) Confidence 0.42 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.20 Pain Relevance 0.07
-specific inhibitor reduced Stat3 activation and IL6-target gene expression and ameliorated disease in colitis-prone IL10-deficient mice [117].
Negative_regulation (reduced) of Gene_expression (activation) of Stat3 associated with colitis and disease
4) Confidence 0.42 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.22 Pain Relevance 0.07
Vorinostat at concentrations capable of producing apoptosis, decreased the expression of Stat6 and phosphor-Stat-6 (but not Stat3 and phosphor-Stat3) were seen in CTCL cell lines and peripheral blood lymphocytes from SS patients (Duvic and Zhang 2006).


Negative_regulation (decreased) of Gene_expression (expression) of Stat3 in lymphocytes associated with lymphatic system cancer, syndrome and apoptosis
5) Confidence 0.41 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721288 Disease Relevance 1.07 Pain Relevance 0
In turn, the anti-IL-6 plus IL-10 Abs partially inhibited the Pam3Cys-stimulated expression, phosphorylation and nucleus translocation of Stat3 (Fig. 2D–F).
Negative_regulation (inhibited) of Gene_expression (expression) of Stat3 in nucleus
6) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.15 Pain Relevance 0
However, TLR4 KD enhanced the phosphorylation and inhibited the expression of Stat3 (Fig. 2C).
Negative_regulation (inhibited) of Gene_expression (expression) of Stat3
7) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.19 Pain Relevance 0.16
Similar to the IL-6- plus IL-10- neutralizing Ab, the TLR2 shRNA markedly inhibited the expression, phosphorylation and nucleus translocation of Stat3, which were partially restored by rmIL-6 and rmIL-10 (Fig. 2D–F).
Negative_regulation (inhibited) of Gene_expression (expression) of Stat3 in nucleus
8) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.16 Pain Relevance 0
In contrast, activation of TLR4 inhibited the expression and phosphorylation of Stat3 (Fig. 2A–D).
Negative_regulation (inhibited) of Gene_expression (expression) of Stat3
9) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.25 Pain Relevance 0.20
Our further observation in Ob-R expression and
               STAT-3 phosphorylation depicted reduced Ob-R expression and STAT-3 phosphorylation
               in both ob/ob age groups. 
Negative_regulation (reduced) of Gene_expression (expression) of STAT-3
10) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.58 Pain Relevance 0
production, leptin treatment
               restored downregulated Ob-R expression and STAT-3 activation in both
                   ob/ob age groups without any effect in lean groups. 
Negative_regulation (downregulated) of Gene_expression (expression) of STAT-3
11) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.44 Pain Relevance 0
In contrast, high levels of p-STAT3 (p = 0.01) and loss of PTEN (p = 0.01) appeared not to be associated with cancer progression.
Negative_regulation (loss) of Gene_expression (levels) of p-STAT3 associated with cancer
12) Confidence 0.23 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.66 Pain Relevance 0
Measured fractions of Specificity protein 1 (Sp1), Signal Transducer and Activator of Transcription (STAT1 and STAT3) and Retinoic Acid Receptor gamma (RAR?)
Negative_regulation (Measured) of Gene_expression (fractions) of STAT3
13) Confidence 0.15 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.36 Pain Relevance 0

General Comments

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