INT228248

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.63
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adam9) extracellular space (Adam9) cell adhesion (Adam9)
plasma membrane (Adam9) cytoplasm (Adam9)
Anatomy Link Frequency
plasma 1
neutrophils 1
Adam9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 46 90.96 High High
Inflammation 58 88.28 High High
Arthritis 2 86.00 High High
Spinal cord 1 62.64 Quite High
cytokine 15 14.24 Low Low
Neuropathic pain 2 13.04 Low Low
Peripheral nerve injury 1 11.20 Low Low
Kinase C 18 5.00 Very Low Very Low Very Low
sodium channel 6 5.00 Very Low Very Low Very Low
IPN 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 60 95.76 Very High Very High Very High
INFLAMMATION 60 88.28 High High
Arthritis 2 86.00 High High
Cancer 34 85.20 High High
Necrosis 9 73.68 Quite High
Disease 157 64.24 Quite High
Alzheimer's Dementia 24 50.00 Quite Low
Nociception 13 49.12 Quite Low
Glioblastoma 1 37.68 Quite Low
Neuropathic Pain 2 13.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-expression of ADAM9 with APP promoted sAPP?
Gene_expression (Co-expression) of ADAM9
1) Confidence 0.45 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.15 Pain Relevance 0.06
generation [49], implying that ADAM9 is involved only in regulated ?
Gene_expression (involved) of ADAM9
2) Confidence 0.39 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.19 Pain Relevance 0.05
production upon phorbol ester treatment, suggesting that ADAM9 possesses ?
Gene_expression (possesses) of ADAM9
3) Confidence 0.39 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.19 Pain Relevance 0.06
The overexpression of both ADAM9 and APP in COS cells led to an increase in the phorbol ester-regulated generation of sAPP?
Gene_expression (overexpression) of ADAM9
4) Confidence 0.38 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0 Pain Relevance 0.05
The plasma membrane expression of EGFR (p = 0.02) and MET receptor (p < 0.0001) and the cytoplasmic proteins ADAM9 (p < 0.001), SRC (p < 0.0001), PKB?
Gene_expression (expression) of ADAM9 in plasma
5) Confidence 0.28 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.58 Pain Relevance 0
can be cleaved by other proteases in addition to caspase-1, including elastase, proteinase 3 matrix metalloprotease 9 (MMP9), which are produced by neutrophils recruited to sites of tissue damage [20-23].
Gene_expression (produced) of proteinase 3 matrix metalloprotease 9 in neutrophils
6) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.52 Pain Relevance 0.29

General Comments

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