INT22825

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Context Info
Confidence 0.25
First Reported 1990
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 36
Total Number 37
Disease Relevance 19.93
Pain Relevance 5.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
heart 2
granulocyte 2
nerve 2
macrophages 1
central nervous system 1
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 43 100.00 Very High Very High Very High
Nerve growth factor 14 100.00 Very High Very High Very High
Hippocampus 61 98.88 Very High Very High Very High
Inflammatory response 7 98.40 Very High Very High Very High
Sciatic nerve 3 98.04 Very High Very High Very High
Central nervous system 60 97.88 Very High Very High Very High
Root ganglion neuron 5 97.40 Very High Very High Very High
rheumatoid arthritis 65 97.08 Very High Very High Very High
withdrawal 21 96.76 Very High Very High Very High
Morphine 204 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 263 100.00 Very High Very High Very High
Injury 50 100.00 Very High Very High Very High
Burns 19 100.00 Very High Very High Very High
Necrosis 15 100.00 Very High Very High Very High
Wound Healing 25 99.84 Very High Very High Very High
Sprains And Strains 96 99.78 Very High Very High Very High
Leukemia 17 99.78 Very High Very High Very High
Nervous System Injury 2 99.60 Very High Very High Very High
Granuloma 6 99.30 Very High Very High Very High
Pancreatic Cancer 58 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of granulocyte-colony stimulating factor on wound healing in a mouse model of burn trauma.
Regulation (Effects) of factor in granulocyte associated with burns, injury and wound healing
1) Confidence 0.25 Published 2004 Journal Tohoku J. Exp. Med. Section Title Doc Link 15329458 Disease Relevance 1.20 Pain Relevance 0.09
The effects of burn trauma and granulocyte-colony stimulating factor (G-CSF) treatment on wound healing in a surgical incision model were studied.
Regulation (effects) of factor in granulocyte associated with burns, wound healing and injury
2) Confidence 0.25 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15329458 Disease Relevance 0.95 Pain Relevance 0.09
Effects of recombinant human Tumor Necrosis Factor (rHu-TNF, PT-050) administered s.c. and i.v. on the central nervous system were investigated behaviorally and physiologically in different animal species.
Regulation (Effects) of Factor in central nervous system associated with necrosis, cancer and central nervous system
3) Confidence 0.13 Published 1990 Journal Arzneimittelforschung Section Abstract Doc Link 2334465 Disease Relevance 0.42 Pain Relevance 0.12
A mouse model of ovarian endosalpingiosis has been developed by directing a dominant-negative version of the TGF-beta transcription factor, Smad2, to the ovary using the Müllerian-inhibiting substance promoter (MIS-Smad2-dn).
Regulation (directing) of factor in ovary
4) Confidence 0.10 Published 2005 Journal Endocrinology Section Abstract Doc Link 16141389 Disease Relevance 0.87 Pain Relevance 0.23
These results suggest that MSP is a peripheral target-derived neurotrophic factor for NGF-responsive adult DRG neurons.
Regulation (target) of factor in neurons associated with nerve growth factor
5) Confidence 0.08 Published 2009 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 19285136 Disease Relevance 0.16 Pain Relevance 0.27
There is strong evidence that after nerve injury leukemia inhibitor factor is a key molecule in the control of peptide expression both in sympathetic neurons and in dorsal root ganglion neurons, although the cells of origin of endogenous leukemia inhibitory factor remain to be established.
Regulation (control) of factor in dorsal root ganglion associated with ganglion cysts, leukemia, nervous system injury and root ganglion neuron
6) Confidence 0.05 Published 1999 Journal Neuroscience Section Abstract Doc Link 10362300 Disease Relevance 0.91 Pain Relevance 0.21
We show that brain granulomas are associated with a significant alteration in the constitutive levels of nerve growth factor (NGF), a trophic factor playing an essential role in nerve growth and differentiation and in preventing neuronal damages.
Regulation (alteration) of factor in nerve associated with nerve growth factor and granuloma
7) Confidence 0.03 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11935373 Disease Relevance 0.84 Pain Relevance 0.27
We show that brain granulomas are associated with a significant alteration in the constitutive levels of nerve growth factor (NGF), a trophic factor playing an essential role in nerve growth and differentiation and in preventing neuronal damages.
Regulation (alteration) of factor in nerve associated with nerve growth factor and granuloma
8) Confidence 0.03 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11935373 Disease Relevance 0.83 Pain Relevance 0.27
CREB is a transcription factor regulated through phosphorylation on Ser133, which is known to play a key role in the mechanism of morphine dependence.
Regulation (regulated) of factor associated with addiction and morphine
9) Confidence 0.02 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19289113 Disease Relevance 0.27 Pain Relevance 1.09
activates mitochondrial biogenesis through a group of transcription factor targets including nuclear respiratory factors 1 and 2 (NRF-1 and -2) and mitochondrial transcription factor A (Tfam), key transcriptional regulators of mitochondrial DNA transcription and replication [8].
Regulation (targets) of factor in respiratory
10) Confidence 0.01 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.36 Pain Relevance 0
Targeted gene disruption revealed Smyd1 to be essential for early cardiac development [14] by acting as a downstream effector of the cardiac transcription factor, MEF2C, in the developing heart [26].
Regulation (effector) of factor in heart
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.05 Pain Relevance 0
For example, Bmal1 transcription is inhibited by REV-ERBa, a transcription factor regulated by adipogenesis [15].
Regulation (regulated) of factor
12) Confidence 0.01 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2807425 Disease Relevance 0.50 Pain Relevance 0
Importantly, while being upstream of Dlx2, which is a direct transcriptional target of Mash1 [30], the latter factor is also known to activate targets that are not shared with Dlx2, suggesting that complete interneuron specification may require the activity of both factors [31],[32].
Regulation (target) of factor in interneuron associated with interneuron
13) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.14 Pain Relevance 0.17
For example, consensus binding motifs are highly enriched in genomic binding sites for the transcriptional repressor REST [7], whereas other factors, including the neuronal activity-regulated transcription factor CREB, are frequently found bound to regions that lack a consensus binding sequence [8].
Regulation (regulated) of factor in neuronal
14) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0 Pain Relevance 0
Strain-dependent regulation of nuclear factor of kappa light chain gene enhancer in B-cells inhibitor ?
Regulation (regulation) of factor in B-cells associated with sprains and strains
15) Confidence 0.01 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.73 Pain Relevance 0.31
Likewise, luteolin down-regulated complement factor 3, which is regulated by AP1 [68] and blocked expression of Slpi, which is a target of interferon regulatory factor 1 (IRF1) [69].
Regulation (target) of factor
16) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.45 Pain Relevance 0.15
influence of the essential oils on nuclear factor ?
Regulation (influence) of factor
17) Confidence 0.01 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233768 Disease Relevance 0.63 Pain Relevance 0.24
For many years investigators have reported acute changes in spinal cord transcription factor levels after noxious formalin stimulation.
Regulation (changes) of factor in spinal cord associated with spinal cord
18) Confidence 0.01 Published 2005 Journal Mol Pain Section Body Doc Link PMC1310513 Disease Relevance 0.43 Pain Relevance 0.26
A recombinant MCMV that expresses green fluorescent protein (GFP) under control of the human elongation factor-1a promoter, inserted at the immediate-early gene (IE2) site (strain K181 MC.55 [ie2?
Regulation (control) of factor associated with cytomegalovirus infection and sprains and strains
19) Confidence 0.01 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.83 Pain Relevance 0.12
Further possible functions of PCI in the developing skin might involve protection from active proteases present in the amniotic fluid, such as uPA and tPA (Verkleij-Hagoort et al. 2007), or regulation of morphogen or growth factor supply in the epidermis, as PCI binds retinoids (Jerabek et al. 2001) and hepatocyte growth factor (HGF) both present in developing skin and amniotic fluid (Laurell et al. 1992; Srivastava et al. 1999).
Regulation (regulation) of factor in hepatocyte
20) Confidence 0.01 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.24 Pain Relevance 0

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