INT228250

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.93
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Smad4) nucleus (Smad4) intracellular (Smad4)
DNA binding (Smad4) protein complex (Smad4) cytoplasm (Smad4)
Anatomy Link Frequency
pancreatic duct 2
Smad4 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 50 100.00 Very High Very High Very High
Adenocarcinoma 120 96.88 Very High Very High Very High
Disease 2 93.36 High High
Malignant Neoplastic Disease 2 84.08 Quite High
Carcinoma 4 78.60 Quite High
Pancreatitis 6 5.00 Very Low Very Low Very Low
Stomach Cancer 2 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most common genetic aberrations in pancreatic duct cell carcinogenesis involve the activation of KRAS oncogene and inactivation of tumor suppressor genes p16/CDKN2, p53 and SMAD4/DPC4 [3].
Positive_regulation (activation) of DPC4 in pancreatic duct associated with cancer
1) Confidence 0.45 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.96 Pain Relevance 0
The most common genetic aberrations in pancreatic duct cell carcinogenesis involve the activation of KRAS oncogene and inactivation of tumor suppressor genes p16/CDKN2, p53 and SMAD4/DPC4 [3].
Positive_regulation (activation) of SMAD4 in pancreatic duct associated with cancer
2) Confidence 0.38 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.96 Pain Relevance 0

General Comments

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