INT228255

Context Info Confidence 0.43 First Reported 2008 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 4 Disease Relevance 1.78 Pain Relevance 0.80

enzyme binding (Akt1, Pten) cytoplasm (Akt1, Pten) nucleus (Akt1, Pten) plasma membrane (Akt1, Pten) phosphatase activity (Pten) mitochondrion (Pten)

Anatomy Link Frequency neuronal 2 ventral 1 Akt1 (Mus musculus) Pten (Mus musculus)

Pain Link Frequency Relevance Heat Ventral tegmentum 24 89.00 Dopamine 345 87.52 Serotonin 9 85.60 midbrain 45 58.72 Chronic pancreatitis 1 25.60 Substantia nigra 24 5.00 Eae 21 5.00 Dynorphin 18 5.00 monoamine 9 5.00 dopamine receptor 9 5.00

Disease Link Frequency Relevance Heat Cancer 46 97.12 Death 27 96.56 Apoptosis 30 92.72 Adenocarcinoma 60 91.08 Brain Tumor 3 79.92 Targeted Disruption 18 72.16 Toxicity 3 71.56 Hypertrophy 9 65.52 Injury 3 38.76 Disease 16 32.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, in recent years investigations have shown cellular functions attributed to PTEN in various neuronal circuits go beyond interactions with the Akt pathway, and have strengthened the current view of this molecule as a potential therapeutic target.

Akt Binding (interactions) of PTEN in neuronal

1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.33 Pain Relevance 0.30

However, in recent years investigations have shown cellular functions attributed to PTEN in various neuronal circuits go beyond interactions with the Akt pathway, and have strengthened the current view of this molecule as a potential therapeutic target.

Akt Binding (interactions) of PTEN in neuronal

2) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.33 Pain Relevance 0.30

In KO animals the loss of PTEN immunoreactivity in the ventral mesencephalon was associated with increased TH and phospho-AKT staining (Figure 1B).

AKT Binding (associated) of PTEN in ventral

3) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.40 Pain Relevance 0.19

Our results further suggest that PKB activity lacked significant association with its antagonistic regulator PTEN as well as with downstream PKB substrates including GSK3?

PKB Binding (association) of PTEN

4) Confidence 0.05 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.73 Pain Relevance 0

General Comments

This test has worked.